This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

bioRxiv · Jun 10, 2024 · PreprintMicrobiology

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

W. Wang, Q. Jin, R. Liu, W. Zeng, P. Zhu, T. Li, T. Wang, H. Xiang, H. Zhang, Q. Chen, Y. Gao, Y. Lai, F. Yan, X. Xia, J. Li, , Y. Gao

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

bioRxiv · Mar 26, 2024Microbiology

Respiration and growth of Paracoccus denitrificans R-1 with nitrous oxide as an electron acceptor

J. Zhou, W. Deng, J. Wu, H. Xiang, J.-G. Lin, Y. Hong

This study investigates the ability of Paracoccus denitrificans R-1 to use nitrous oxide as an electron acceptor for energy generation and growth, showing it can reduce N2O to N2 under anaerobic conditions.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Degenerated CRISPRs widely regulate Cas expression to balance immunity and cost

C. Liu, R. Wang, J. Li, F. Cheng, X. Shu, H. Zhao, Q. Xue, H. Yu, A. Wu, L. Wang, S. Hu, Y. Zhang, J. Yang, H. Xiang, M. Li

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

Tat-fimbriae ("tafi") - novel type of haloarchaeal surface structures

A. V. Galeva, A. S. Syutkin, D. Zhao, I. I. Kireev, A. K. Surin, E. Y. Pavlova, J. Liu, H. Xiang, M. G. Pyatibratov

This study identifies and characterizes tat-fimbriae (tafi), novel haloarchaeal surface structures formed via the Tat-pathway, and demonstrates their synthesis in a heterologous host.

bioRxiv · Mar 6, 2023 · PreprintMicrobiology

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

Y. Li, J. Qi, Y. Liu, Y. Zheng, H. Zhu, Y. Zang, X. Guan, S. Xie, H. Zhao, Y. Fu, H. Xiang, W. Zhang, H. Chen, H. Liu, Y. Zhao, , Y. Liu

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

bioRxiv · Feb 20, 2023 · PreprintBioengineering

The nematode effector Mj-NEROSs interacts with ISP influencing plastid ROS production to suppress plant immunity

B. Stojilkovic, H. Xiang, Y. Chen, L. Bauters, H. Van de Put, K. Steppe, J. Liao, J. de Almeida Engler, G. Gheysen

The paper identifies Mj-NEROSs, an effector from root-knot nematodes, which suppresses plant immunity by interacting with ISP in plastids to reduce ROS production.

bioRxiv · Oct 24, 2022Plant Biology

Comparative genomic insights into the evolution of Halobacteria-associated "Candidatus Nanohaloarchaeota"

D. Zhao, S. Zhang, S. Kumar, H. Zhou, Q. Xue, W. Sun, J. Zhou, H. Xiang

This paper identifies a new family of 'Ca. Nanohaloarchaeota' from hypersaline environments, showing they are an intermediate stage in the evolution of symbiosis with Halobacteria.

bioRxiv · May 20, 2022Microbiology

Cohesin mutation sensitizes cancer cells to anti-PD-1 therapy through endogenous retrovirus-mediated PD-L1 upregulation

Y. Han, F. Peng, Y. Chang, T. Liu, J. Shen, Z. Chen, P. Zhou, F. Jiang, H. Xiang, H. Zhu, C. Qing, X. Kong, J. Ding, J.-Y. Lang

This study shows cohesin mutations enhance cancer cell sensitivity to anti-PD-1 therapy by increasing PD-L1 through endogenous retrovirus activation.

bioRxiv · Feb 19, 2022 · PreprintCancer Biology

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

A. Chen, S. Liao, M. Cheng, K. Ma, L. Wu, Y. Lai, X. Qiu, J. Yang, W. Li, J. Xu, S. Hao, X. Wang, H. Lu, X. Chen, X. Liu, , J. Wang

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

bioRxiv · Jan 17, 2021Cell Biology

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

H. Xiang, Y. Zhao, X. Li, P. Liu, L. Wang, M. Wang, L. Tian, H. Sun, W. Zhang, Z. Xu, B. Ye, X. Yuan, P. Wang, N. Zhang, Y. Gong, , P. Yang

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

bioRxiv · Dec 28, 2020Immunology

CTP synthase forms cytoophidia in archaea

S. Zhou, H. Xiang, J.-L. Liu

This study shows that CTP synthase forms cytoophidia in archaea, extending the known presence of these structures to all three domains of life.

bioRxiv · Jan 23, 2020Cell Biology

Native CRISPR-Cas mediated in situ genome editing reveals the exquisite interplay of resistance mutations in clinical multidrug resistant Pseudomonas aeruginosa

Z. Xu, M. Li, Y. Li, H. Cao, P. C. Woo, H. Xiang, A. Yan

This study uses native CRISPR-Cas genome editing to analyze resistance mechanisms in a multidrug-resistant Pseudomonas aeruginosa strain, revealing synergistic effects between efflux pumps and target mutations.

bioRxiv · Jan 8, 2019 · PreprintMicrobiology

Artificial Selection on Storage Protein 1 Contributes to Increase of Hatchability during Silkworm Domestication

Y. n. Zhu, L. Z. Wang, C. C. Li, Y. Cui, M. Wang, Y. J. Lin, R. P. Zhao, W. Wang, H. Xiang

This study identifies SP1 as a target of artificial selection in silkworms that enhances egg hatchability by improving nitrogen utilization and biosynthesis pathways.

bioRxiv · Aug 9, 2018Evolutionary Biology