X. Dong

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

The paper analyzes viral diversity in deep sea cold seep sediments, finding high endemism and links to microbial hosts and biogeochemical cycling.

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

This study examines the relationship between motor fitness, fundamental movement skills, and functional movement screen in primary school children, finding weak correlations and suggesting independent systems in motor development.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The paper examines how PD-L1 expression on tumor cells affects specific cell clusters in TCR-T cells through single-cell RNA sequencing and cytotoxicity assays.

This study shows that bacterial outer membrane vesicles from pathogenic and beneficial Pseudomonas species activate plant immune responses, offering protection against pathogens and revealing distinct mechanisms of action.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

The paper identifies genetic elements and QTL associated with stem prickle development in roses, linking prickle density to water-related adaptations.

The paper introduces ctmmweb, a graphical interface for autocorrelation-informed home range estimation, demonstrating its use on jaguar tracking data.

The paper shows mitochondria form contact sites with the nucleus to facilitate a pro-survival retrograde response by stabilizing transcription factors like NF-kB.

This study profiles microbial activities in deep sea cold seep sediments, revealing hydrocarbon oxidation pathways and their role in sustaining diverse microbial communities across redox gradients.

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

This study uses genome-wide sequence data to reconstruct the phylogeny of diploid wheat wild relatives and identifies recurrent hybridization events shaping their evolution.

The paper develops a high-content Virion Display (VirD) array of human GPCRs to profile their biochemical activities and identifies potential drug targets.

The paper identifies a shared core microbiome across distant soda lakes and suggests common design principles for high productivity.

This paper determines the structural basis of how Rpn13 recognizes K48-linked Ub chains through a bivalent interaction, revealing a mechanism for proteasomal selectivity.

This study investigates microbial energy and carbon acquisition strategies in deep-sea petroleum seeps using metagenomic analysis and geochemical data.

The paper identifies BAP1 loss as a marker for a distinct immunogenic PeM subtype, suggesting potential therapeutic targets like immune checkpoint inhibitors.

This study identifies a deletion in TMPRSS6 associated with reduced hemoglobin and improved blood viscosity in Tibetan pigs adapted to high altitude.

This study characterizes the structure, function, and dynamics of the gamete fusogen HAP2, revealing dynamic regions and structural features critical for fusion.

This paper introduces a metaproteomics method called direct Protein-SIF and software to measure carbon isotope ratios in microbial communities, confirming its accuracy and utility in studying microbial metabolism.

The paper determines the structure of pro-TGF-β1 with a cleavage site mutation, revealing prodomain-GF domain swapping in the dimeric structure and its implications for TGF-β biosynthesis.

The paper develops metaproteomics methods to assess microbial community composition by measuring biomass contributions through protein abundance, validated using artificial communities and applied to environmental and saliva samples.