Y. Gao

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.

This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.

The paper analyzes ANI values across microbial genomes and argues that the observed bimodal distribution does not support a universal genetic boundary due to sampling biases and inflated benchmarks.

The paper investigates denitrification in Bradyrhizobium isolates, finding that only ~1/3 can reduce N2O, with proteomics showing Nos outcompetes Nap for electrons.

This study identifies multi-site oxidations and amino acid substitutions in urinary proteins as age-related features by comparing three age groups using mass spectrometry and statistical analysis.

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

The paper presents a near-complete yeast proteome dataset using optimized sample preparation and high-resolution mass spectrometry, identifying 5610 proteins with 94.1% coverage of yeast ORFs.

This study examines the expression of Ace2, Tmprss2, and Furin in mouse ear tissues, finding co-expression in the middle ear that suggests susceptibility to SARS-CoV-2.

This study identifies lipid differences in plasma, microvesicles, and exosomes between preterm and full-term pregnancies, finding microvesicle lipids better predict preterm birth risk.

This study shows that beige adipocytes can improve glucose metabolism and energy expenditure in the absence of brown adipose tissue in vivo.

This study shows that the antimicrobial peptide apidaecin inhibits translation by arresting ribosomes at stop codons and causing stop codon bypass, leading to C-terminal extensions on proteins.

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

This study shows that blocking CTLA-4 reverses Treg cell suppression of anti-TB T-cell responses in tuberculosis patients.

This paper introduces a method to infer the order of somatic mutations in cancer progression using noisy single-cell sequencing data and demonstrates its effectiveness through simulations and empirical data.

The paper shows that YdhB (AdnB) activates ydhC gene expression in E. coli, encoding an adenosine/adenine transporter, and demonstrates its role in nitrogen metabolism and growth under specific conditions.

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

The paper shows that egg-surface bacteria in Bactrocera dorsalis increase β-caryophyllene in fruits, deterring oviposition by conspecific flies.

This study shows that immunization with SARS-CoV-2 RBD elicits potent neutralizing antibodies without antibody-dependent enhancement in rodents.

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

The paper identifies differential proteins in urine of tumor-bearing mice, showing early biomarker potential for melanoma and prostate cancer.

The paper reports a cryoEM structure of the PDE6 complex with GTP-bound transducin, revealing its catalytic mechanism and conformational dynamics.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study compares global chemical modifications in human plasma proteomes between young and old age groups, identifying four significant differences in modifications such as succinylation, phosphorylation, and carbamylation.

This paper uses solid-state NMR to show that 150 kDa Aβ(1-42) oligomers contain both parallel and antiparallel β-sheets with a unique inter-strand registry shift.

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

This study shows that SepF protein rings in bacteria control septal thickness, with ring diameter correlating to septum thickness and manipulation of ring size altering septum thickness.

This study identifies new antigenic sites on GII.4 norovirus capsid protein through population genomics, linking specific residues to variant emergence and vaccine design.