H. Huang

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

This study maps transcriptional and epigenetic changes in CD8 T cell differentiation using scRNA-seq and scATAC-seq, revealing shared biological circuits across effector, memory, and exhausted cell fates.

This study identifies six thiolases in Aspergillus oryzae and shows their roles in fatty acid and ergosterol biosynthesis, with some exhibiting dual functionality.

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

This study identifies the Rac-NOX2 complex as a driver of redox signaling in FLT3-mutant AML, showing that inhibiting NOX2 reduces key signaling pathways and enhances response to FLT3 inhibitors.

The paper uses proteomics to compare immune responses to Salmonella Typhimurium infection in two mouse strains, identifying differentially expressed proteins and pathways involved in resistance.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

The paper examines the coevolution between rice landraces and their blast pathogen in China, finding that generalist pathogen lineages coexist with host genetic subdivision.

This study identifies two distinct H3 binding modes of NASP and shows how they cooperate to maintain histone H3-H4 homeostasis.

The paper identifies a novel cyanobacterial symbiont in the coral-killing sponge Terpios hoshinota, characterizes its genome and metabolic potential, and proposes a new genus and species.

This study uses single-cell sequencing to identify distinct immune features and CCR6-CCL20 crosstalk in hereditary versus idiopathic chronic pancreatitis.

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study shows that Tsr3 establishes a hierarchy between Rio2 and Rio1 kinases during 40S ribosome assembly by preventing Rio2 rebinding and enabling Rio1 recruitment.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study identifies a distinct CD8+γδ T cell population in controlled Mtb infection that exhibits NK-like cytotoxicity and stage-specific antigen recognition.

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

The paper shows that Rrp36 regulates ribosome assembly by preventing a dead-end pathway, allowing Has1 to correct misfolding and ensure proper platform assembly.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study shows that late gestation transient prenatal hypoxia in mice leads to long-term functional deficits without gross anatomical brain damage.

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper examines ethical issues in disease naming and proposes a method using deep learning to find suitable substitutes for outdated disease names.

This study uses integrative omics to detect subtle molecular changes in porcine kidneys after remote ischemic conditioning, finding reduced inflammation and potential fibrosis markers.