J. Chen

This study investigates appetite-regulating gene expression in zebrafish gut under different feeding conditions, identifying leptin-dependent differential expression of anorexigenic genes.

This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

This paper develops a deep multiple instance learning model to predict tumor purity from histopathology slides, showing spatial variation and improving sample selection for genomic analysis.

This study determines the mechanism by which two FDA-approved CFTR correctors stabilize the misfolded ΔF508 mutant by binding to a hydrophobic pocket in TMD1.

This study identifies MIP-1 and MIP-2 as C. elegans germ granule proteins that recruit Vasa homolog GLH-1 and are essential for granule formation and germ line development.

This study shows that inhibiting EPAC1 protects the heart from doxorubicin-induced toxicity without affecting its cancer-killing effects.

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This paper introduces SEER-FISH, a method for spatially profiling microbial communities with high multiplexity and accuracy, demonstrating its ability to quantify taxon abundance and map microbial biogeography.

This study tracks genomic changes in European oaks since the Little Ice Age, finding shifts in selection linked to climate extremes and stress responses.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

This study identifies miR-2 as a regulator of Caspase 2 in mud crabs, showing it suppresses WSSV infection through apoptosis induction.

This paper identifies new regulators of sRNA signaling in E. coli using a fluorescence-based genetic screen, revealing both general and RyhB-specific mechanisms.

This study shows that ZFP36L1 deficiency protects mice from alcohol-induced liver steatosis and inflammation by stabilizing Fgf21 mRNA.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

This study tests a T cell vaccine in HLA-A*02:01 mice to assess its immunogenicity against SARS-CoV-2 variants.

This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.

The paper shows that SAC gene expression in fission yeast is fine-tuned through codon usage and mRNA/protein half-life strategies to ensure proper checkpoint function.

This paper introduces a hierarchical Bayesian calibration method for dynamic vegetation models, showing it improves prediction accuracy by accounting for site-to-site parameter variability.

The paper transplants mouse high fat diet microbiota into zebrafish larvae to identify microbial factors that accelerate hyperlipidaemia via MyD88 signaling.

This study shows YTHDF2, an m6A reader, enhances NK cell anti-tumor and anti-viral responses by regulating homeostasis, maturation, and effector function through STAT5 feedback and Tardbp interactions.

The paper defines the role of wild-type and patient-specific TP53 mutations in ERMS using zebrafish models, showing tp53 loss increases tumor initiation and identifying mutation-specific effects on tumor development.

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

This study shows that rat mesenchymal stem cells express Ang1 and Ang2, which are upregulated during osteogenesis in vitro.

This study identifies high-frequency SARS-CoV-2 mutations that may compromise multiple monoclonal antibody therapies in clinical trials using a topology-based deep learning approach.

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.