J. Chen

Colonic oxygen microbubbles improve systemic oxygenation and reduce CO2 levels in pigs with smoke inhalation-induced severe hypoxia.

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

This paper introduces an imaging-guided bioreactor for de-epithelialization and long-term cultivation of ex vivo rat trachea, enabling real-time monitoring and cell replacement for bioengineered tissue applications.

This study shows that elevated PGE2 in aged lungs impairs alveolar macrophages, leading to increased mortality from influenza infection.

This study uses molecular dynamics simulations to show that the CTH of D3 stabilizes inactive conformations of D14 and blocks SL binding, inhibiting strigolactone signaling.

This study benchmarks eleven tools for inferring kinetic rate constants from smFRET trajectories using simulated and experimental data with varying challenges.

This study shows that glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal communities in rat caecum microbiomes, with formulations causing more pronounced changes than glyphosate alone.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study uses cryo-EM and simulations to identify four conformational states of the nsp13 helicase in the SARS-CoV-2 RTC, revealing an allosteric mechanism for switching between RNA synthesis and backtracking.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

This study identifies reduced Annexin A1 levels in dengue patients and mice, showing that AnxA1 agonists reduce disease severity by modulating mast cell degranulation.

This paper introduces a ratiometric multi-color imaging strategy for 4Pi-SMLM that achieves optimal 3D resolution and color separation with minimal loss of localization precision.

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This study examines beetle evolution through the end-Permian mass extinction, showing xylophagous beetles declined due to forest collapse and later rebounded with forest recovery.

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

This study tests heat inactivation of coronaviruses on vehicle surfaces using BCoV as a surrogate for SARS-CoV-2, finding 56°C heat effectively reduces infectivity.

This study determines the structural basis of RNA polymerase open complex stability in E. coli by analyzing three promoters with different lifetimes using cryo-EM.

This study identifies α-taxilin and γ-taxilin as new components of centriolar subdistal appendages, showing their role in microtubule anchorage and spindle orientation.

The paper investigates the prevalence and evolution of exonic regulatory sequences, finding that exonic TFBSs are common and may evolve into regulatory elements when non-exonic sequences are unavailable.

The paper identifies a secretory subset of multipotent hematopoietic progenitors that enhance myelopoiesis during stress and disease by amplifying myeloid cell production through cytokine secretion.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

The paper challenges the universal ERP model of temperate phage life cycles by showing wildtype P22 follows an RPE program, optimizing gene transfer for host evolution.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

This study identifies a novel MarR subfamily, MarRars, that regulates arsenic resistance genes by responding to As(III) and Sb(III) and repressing arsV expression.

The paper investigates how cell size scaling affects proteome organization and organelle content, linking these changes to senescence-like features in human cells.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.