J. Lee

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

The paper uses single-cell methods to explore the complexity of the mononuclear phagocyte compartment in the human intestinal lamina propria, identifying distinct subsets, site-specific signatures, and lineage-specific precursors.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

The paper identifies key receptor-like protein genes in pepper that confer broad-spectrum resistance by analyzing co-expression networks across multiple pathogen infections.

The paper identifies IgM+ and IgM- memory B cells that can differentiate into plasmablasts and germinal center B cells upon re-challenge with P. yoelii.

This paper introduces an improved feature detection framework to segment cardiomyocyte nuclei in zebrafish hearts, enabling quantitative analysis of cardiac contractility across developmental stages.

The paper develops a deep-learning method to segment and analyze cardiac mechanics in developing zebrafish, revealing incremental volume changes in ventricles and stable stroke volume in atria.

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

This study shows that copper competition between methanotrophs and denitrifiers in rice paddy soils increases nitrous oxide emissions through methanobactin-mediated copper sequestration.

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

The paper uses 4DHiC to reconstruct 3D chromosome dynamics, showing X-chromosome reorganization during inactivation involves persistent smaller structures and Xist RNA diffusion.

This study identifies dermatan sulfate (DS) as a master regulator of IgH in pre-B cells by interacting with pre-BCR components, GTF2I, and ER proteins, influencing autoreactive B cell development and autoimmunity.

This study combines enhanced biological phosphorus removal with nitrite accumulation in a reactor treating synthetic digested manure wastewater, achieving high phosphorus removal and stable nitrite levels.

This paper introduces a deep learning method to improve high-content screening for Alzheimer's disease therapeutics by generating predicted fluorescent signals from alternative markers.

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.

This study compares the recurrence rates of involutional lower eyelid entropion correction using everting sutures alone versus lateral tarsal strips with or without everting sutures, finding the latter significantly reduces recurrence.

The paper optimizes the production process for a SARS-CoV-2 vaccine candidate, achieving high yield and purity through yeast fermentation and chromatographic purification.

The paper investigates the dimerization behavior of F220C rhodopsin mutant and wild-type opsin in vitro and in the plasma membrane, finding that the mutant forms a unique dimer with distinct conformational features.

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

The paper identifies prevalent, protective, and convergent IgG antibodies targeting non-RBD epitopes of SARS-CoV-2 spike protein in convalescent plasma.

This paper identifies gp56, a bacteriophage protein, as an inhibitor of Bacillus subtilis cell division by blocking recruitment of late division proteins through interaction with DivIC/FtsL.

The paper evaluates the quality of specimens and results from a home-based respiratory surveillance study to assess its feasibility for community-level monitoring of respiratory pathogens.

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

The paper identifies key host and viral RNA-binding proteins involved in SARS-CoV-2 infection and shows that drugs targeting these proteins can inhibit infection.

The paper investigates nuclear transport in phage infection systems, finding that GFPmut1 can be selectively transported into the {Phi}KZ phage nucleus, with specific amino acid residues identified for this process.

This study develops and tests bat influenza-based live attenuated vaccines for pigs, showing they reduce viral replication and lesions without causing vaccine-associated enhanced respiratory disease.

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.