J. Wang

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This paper introduces LiGaMD2, a method that improves ligand binding thermodynamics and kinetics calculations by enhancing sampling of closed protein pockets.

This study identifies age-related changes in the insoluble proteome of mouse brains, showing a shift in protein characteristics associated with proteostasis decline.

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

This study shows chemotherapy-induced reactive myelopoiesis and FX-expressing macrophages promote cancer lung metastasis through CCL2/CCR2 axis and coagulation-inflammation interplay.

This study isolates a CPR bacterium using epicPCR and reveals its type IV pili-dependent epibiotic lifestyle and twitching motility.

The paper identifies a cell surface-triggered auxin signaling mechanism that regulates PIN1-mediated auxin efflux and developmental patterning in Arabidopsis.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

This paper introduces a deep learning framework for simultaneous self-denoising and segmentation of VIS-OCT retinal images, showing improved segmentation performance with reduced annotation requirements.

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

This study infects human iPSC-derived CNS and PNS neurons with SARS-CoV-2 and finds that PNS neurons experience more severe neurodegeneration linked to innate immune activation.

The paper shows Runx factors regulate T-cell and innate lymphoid programs through dynamic binding and gene network interactions during early development.

The paper uses amplicon sequencing to analyze parasite strain diversity in mothers and infants infected with Trypanosoma cruzi, finding multiple strains in some individuals and increased diversity in infants post-birth.

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

This study identifies NlpE as an OmpA-associated sensor that activates the Cpx envelope stress response in surface-adhered Gram-negative bacteria by transducing signals from OmpA overexpression.

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

The paper investigates the role of TPLATE complex-dependent endocytosis in regulating CLAVATA1 signaling in Arabidopsis shoot apical meristem maintenance.

The paper introduces a kinase inhibitor pulldown assay (KiP) combined with PRM for clinical proteomics, improving kinase quantification in cancer samples.

The paper tests Darwin's hypotheses on alien plant invasion success by analyzing phylogenetic relationships across invasion stages and environmental contexts.

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

The paper analyzes NIH Research Project Grant costs from 1998 to 2021, finding stable real costs post-2003 despite nominal increases and higher proportion of solicited projects.

This paper introduces a second-generation dual-channel VIS-OCT system that achieves wide-field, full-range, and shot-noise limited retinal imaging with improved depth resolution and SNR.

This paper introduces a hybrid method combining a physical model with deep learning to improve structured illumination microscopy, achieving better artifact suppression and resolution in low SNR images.