J. Wang

This study identifies host-specific metabolites that enhance Vibrio mimicus infectivity in yellow catfish by providing nutrients like deoxyguanosine.

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

This study investigates how emotional state changes affect memory of temporal order and duration, finding that negative events compress time while shifts to negative events dilate time.

The study identifies SARS-CoV-2 Mpro mutations associated with nirmatrelvir resistance from clinical isolates.

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

This study characterizes RBM15's RNA binding mechanism through bioinformatics and experiments, showing it interacts with stem-loop RNA motifs via RRMs 2 and 3.

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

The paper measures baseline Bacteroidales concentrations in romaine lettuce fields to assess fecal contamination risk and proposes a method to complement current environmental assessments.

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

The paper assesses the distribution and genetic diversity of Hipposideros pratti in its northernmost range, finding limited distribution, low genetic diversity, and human threats.

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

The paper characterizes BDW568, a non-nucleoside STING agonist, showing it activates STINGA230 variants in human cells and mimics endogenous ligands.

This study identifies Prmt5 as a negative regulator of neuronal survival during cerebral ischemia and shows that its inhibition protects against neuronal death in a mouse model.

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

This study shows TRAF6 initiates inflammatory signaling by forming membraneless condensates through phase separation, which activates NF-κB signaling.

This paper develops a pneumatically controlled cell stretcher with live-cell imaging to study mechanical strain effects on cell behavior.

This study examines gene family evolution in herbivorous Drosophila to understand dietary adaptation, finding higher gene turnover in herbivores but limited losses on the ancestral herbivore branch.

This study identifies WBSCR16 as a key regulator of metabolic flexibility by controlling mitochondrial 16S rRNA maturation and switching between glucose and lipid metabolism.

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

This study identifies dynamic transcriptional changes during the dimorphic transition of Talaromyces marneffei using a novel model, DyGAM-NS, and reveals asymmetrical gene expression patterns and regulatory networks.

This study shows that Slc30a1 in macrophages protects against Salmonella infection by maintaining zinc homeostasis and reducing oxidative stress.

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

The paper identifies the BcTir/Tpr system in Bacillus cereus as a defense mechanism against phage infection, showing BcTpr's dual role in NAD+ depletion and cADPR isomer production.

This study shows that TRAIL+ cancer cells use noncanonical TRAIL signaling in MDSCs to promote their abundance and tumor progression in cholangiocarcinoma.

The paper identifies a Ctsk+Fmod+ periosteal cell subset in jaw bones that is impaired by Spp1 secreted by macrophages, highlighting a potential target for improving bone grafting.

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.