J. Wang

The paper identifies a protein complex that promotes early endosome bud biogenesis through lipid transport at Golgi-endosome contacts.

This study shows that inhibiting MAO-A in cardiomyocytes reduces arrhythmias by improving diastolic calcium control following catecholamine stress.

The paper develops a computational model to study microtubule-cytoplasm interaction in plant cells, showing microtubules align orthogonally to cell elongation and matching experimental results.

The paper introduces an automated high-throughput system for plant imaging and phenotyping, demonstrating its ability to analyze large-scale plant-microbe interactions across diverse nutrient environments.

This study shows Bordetella spp. block eosinophil recruitment to prevent iBALT formation, which suppresses immune responses and promotes bacterial persistence.

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

This study shows that MyD88-dependent signaling is critical for TLR-mediated trained immunity in macrophages, as demonstrated through experiments in mice and human cells.

This paper introduces a new vaccine evaluation system based on pathogen clearance and liver trapping to assess immunoprotective potential against bacterial infections.

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

This study shows that bempedoic acid reduces cyst growth in ADPKD cells and mice, and combining it with tolvaptan enhances therapeutic effects.

This study examines tRNA transcriptomes and translatomes in mouse tissues to explore their relationship with translational efficiency and tissue-specific proteomes.

This study uses a yeast-based system to identify nirmatrelvir-resistant mutations in SARS-CoV-2 Mpro and confirms findings with structural analysis.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

This study identifies a senescent preosteoclast secretome-COX2/PGE2 axis as a driver of metabolic syndrome-associated osteoarthritis, with selective COX2 inhibitors showing therapeutic potential.

This study uses molecular dynamics simulations to analyze how different intervals between bipolar pulses affect phospholipid membrane electroporation, identifying three states and their dynamics.

This study uses molecular dynamics simulations to investigate how phospholipid composition and cholesterol content affect electroporation in lipid bilayers.

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

The paper identifies a multipotent lung progenitor that co-expresses endothelial and epithelial markers and contributes to multi-lineage regenerative patches in a transplantation model.