K. Li

This study investigates the therapeutic effect of NF-κB decoy ODN-loaded PLGA nanospheres in reducing alveolar ridge resorption after tooth extraction in rats.

This study introduces a matrix completion method to predict chemical-target interactions, achieving high accuracy and demonstrating its utility for prioritizing environmental chemicals.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

This study develops a mathematical model to analyze viral dynamics in HP and LP influenza infections, finding HP viruses have higher infection rates and lower interferon production, leading to more severe tissue damage.

This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

The paper compares the effects of local and landscape-scale factors on seasonal bee communities to guide land management practices.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

The paper shows that aging-related iron accumulation reduces estrogen receptor expression, diminishing the benefits of hormone replacement therapy in late postmenopausal women with atherosclerosis.

This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

This study uses a VAE to map fMRI data into a latent space, enabling the modeling of transient co-activity patterns and their temporal dynamics.

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

CHA1, a combination of EGCG and decitabine, reprograms TNBC tumors and their microenvironment by inhibiting Wnt and activating JAK/STAT/IFN signaling, enhancing PD-L1 expression and T-cell infiltration.

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

This paper introduces a synthetic carbon fixation cycle in plants that fixes CO2 without RuBisCO, showing increased photosynthetic capacity in transgenic Camelina sativa.

This study creates a genome-wide atlas of antibiotic susceptibility targets in Streptococcus pneumoniae, identifying a 'tolerome' that influences resistance and highlights its evolutionary significance.

This paper designs and evaluates PROTACs that use L3MBTL3 to induce nuclear-specific degradation of FKBP12 and BRD2 by hijacking a methyl reader:E3 ligase complex.

This study examines the microbiota of adults with cystic fibrosis (CF) and finds low diversity and instability in sinus microbial communities, linked to inflammation and worse sinus disease.

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

This paper develops a mass spectrometry method to detect microproteins in vaginal lavages and identifies cystatin A as a potential biomarker for early ovarian cancer detection.

Cryo-electron microscopy reveals a near-atomic structure of an infectious, brain-derived murine prion fibril and strain differences.

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

This paper introduces SHARC, a method to measure RNA 3D distances and alternative conformations in cells, revealing RNA structures and improving 3D modeling.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

The paper describes methods to produce pure, active mixed isotopically labeled dimer of chorismate mutase using CuAAC for structural studies of allostery.

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

This study models how MUC1 affects influenza virus infection and macrophage dynamics, finding it reduces viral reproduction and macrophage recruitment but not viral load.