L. Cao

The paper presents two neural network models for predicting and generating stable proteins based on amino acid sequences, showing improved stability in both expert-designed and model-generated proteins.

This study evaluates the protective efficacy of modified miniproteins against SARS-CoV-2 in mice, showing reduced viral burden and prevention of lung disease.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

This study shows that HIV-1 signal peptide diversity affects Env glycosylation and antibody recognition of V1V2 epitopes.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

This study identifies the C-terminal motifs of epsin proteins as critical for their localization and function in cancer cell migration and invasion, with clathrin-binding motifs being most important.

This study introduces a statistical method to analyze mutation dynamics in influenza A H3N2, showing regional mutation contributions to global epidemics and identifying key amino acids for therapeutic targets.

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

The paper shows that the WASH complex interacts with Dynactin and uncaps it, allowing the Arp1/11 minifilament to prime Arp2/3 complex-mediated actin branching at endosomes.

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper identifies Apaf-1 pyroptosome as a machinery that senses mitochondrial permeability transition (MPT) and triggers pyroptosis via caspase-4/11 and GSDME.

The paper determines cryo-EM structures of human Arp2/3 complexes with different ARPC5 isoforms to show how isoform variation affects complex activity.

The paper shows that stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to epinephrine and enhancing insulin sensitivity in adipose tissues.

This study shows that reducing nicastrin in human cell lines increases type-I interferon gene expression and alters NFKB signaling, suggesting a role in HS pathogenesis.

This study investigates how profilin and mechanical tension modulate formin mDia1 processivity by altering dissociation rates from actin filaments.