L. Wang

This study examines how high temperatures affect grape berry metabolism at different developmental stages using proteomic and metabolomic analyses, identifying key proteins and metabolic changes linked to heat stress.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

This study shows that proteolytic cleavage, not receptor binding, is the main barrier for two MERS-like bat coronaviruses to infect human cells, and that trypsin treatment can overcome this barrier.

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.

This study compares cold resistance in two discus fish species using antioxidant indexes, finding interspecific variation linked to environmental adaptation.

This paper identifies Bacillus subtilis WL-2 and its IturinA lipopeptides as effective inhibitors of Phytophthora infestans mycelium growth through mechanisms involving cell membrane damage, oxidative stress, and mitochondrial dysfunction.

This study shows that MCL-1 inhibition by BH3 mimetics disrupts mitochondrial dynamics and function in iPSC-derived cardiomyocytes, suggesting a non-apoptotic role for MCL-1 in cardiac health.

The paper examines the roles of three wheat glutamine synthetase isozymes in nitrogen assimilation and translocation, showing distinct functions and synergistic effects.

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

The paper uses single-cell RNA-seq to analyze human Wharton’s Jelly-derived MSCs, identifying heterogeneity in gene expression and potential marker genes for potency.

This study shows AGO2 is required for pancreatic cancer progression but not initiation, with its role dependent on mutant KRAS and EGFR signaling.

This study characterizes the single Shaker K+ channel in Medicago truncatula, MtGORK, and shows its roles in K+ translocation and stomatal control, while demonstrating its dispensability for rhizobial symbiosis.

This study shows diurnal variation in xylem water isotopes biases root water uptake depth estimates and proposes monitoring sap flow and soil water potential to improve accuracy.

The paper shows that ASCL1-regulated DARPP-32 and t-DARPP promote SCLC growth and survival through Akt/Erk signaling and anti-apoptotic pathways, with t-DARPP overexpression linked to Notch signaling activation in SCLC patients.

This study shows Notch3 promotes osteoblastic bone lesions in prostate cancer by inhibiting osteoclasts and enhancing osteoblasts through MMP-3.

This study evaluates LSD1 inhibitors in DIPG, showing selective cytotoxicity and an immune gene signature linked to NK cell activity, with potential therapeutic implications.

The paper develops a strategy to create fluorogenic probes for live-cell nanoscopy with high cell permeability and low background signal.

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

This study identifies distinct acylcarnitine metabolomic profiles associated with different subtypes of major depressive disorder following SSRI treatment.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This paper introduces a novel reporter gene assay for pyrogen detection using NF-κB activation in RAW 264.7 cells, showing sensitivity and applicability to various biological products.

This study shows PID1 increases lipolysis by inhibiting insulin's antilipolytic effect through the AKT/PKA/HSL pathway in adipose tissue.

This study shows nintedanib reduces vascular remodeling in pulmonary arterial hypertension by inhibiting endothelial mesenchymal transition and smooth muscle cell proliferation.

This study shows that p62-mediated selective autophagy in virus-transformed cells protects against DNA damage under oxidative stress by regulating CHK1 and RAD51 protein stability.