L. Wang

This paper introduces a method to measure aptamer folding energy using a molecular clamp and validates it with experimental results for two aptamers.

This study shows that weak predation strength promotes stable coexistence of predators and prey in food webs, supported by empirical data from plankton communities.

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

This study shows that silicon enhances plant resistance against powdery mildew through distinct, multi-layered defense mechanisms involving PAD4-dependent and SA-independent pathways.

The paper shows that the TYLCV protein V2 suppresses viral genome methylation in plant Cajal bodies by interacting with AGO4.

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

The paper shows TCF-1 enhances HIV-specific CD8+ T cell expansion and memory properties in elite controllers.

This study determines the structure of hDGAT1 with a substrate, revealing its homodimeric organization and substrate-binding sites.

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

The paper uses single-cell RNA sequencing to analyze immune cell composition in brain metastases of NSCLC patients, finding reduced T cell activity and expanded M2-polarized tumor-associated macrophages.

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

The paper introduces a bioreactor that uses electric fields to guide cell migration in real-time, demonstrating precise 2D collective migration maneuvers in renal epithelia and skin keratinocytes.

The paper introduces a microbial microdroplet culture system (MMC) that enables automated, high-throughput microbial cultivation and adaptive evolution, showing improved growth rates compared to conventional methods.

This study shows nilotinib activates endothelial TLR4, promoting atherosclerosis, and suggests TLR4 inhibition could mitigate this effect.

This study investigates how the feeding behavior of Monochamus alternatus affects the departure of pine wood nematodes, finding no significant difference but linking increased motility and oxidative phosphorylation to nematode departure.

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

The paper identifies an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies, showing its role in stress tolerance and 3D growth.

The paper shows that weak, liquid-like interactions between Eps15 and Fcho1 enable efficient endocytosis by promoting dynamic protein assembly and preventing stalling of vesicle budding.

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

The paper systematically analyzes correlations between 221 physical examination indicators in healthy and disease states, identifies disease markers, and develops machine learning models to predict health status with high precision.

This paper reveals the atomistic mechanism of NompC channel opening under intracellular compression using simulations and experiments, showing force transmission through ankyrin repeats and linker helices to the TRP domain.

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

This study shows that the mouse superior colliculus is causally involved in visual perceptual decision-making by demonstrating that its inhibition impairs detection of orientation changes in the contralateral visual field.

This study examines how drought and chilling stresses individually and together affect maize growth and oxidative metabolism, finding that combined stress is more harmful than either alone, with hybrids better tolerating stress than inbreds.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.

This paper shows that using multiple low doses of drugs targeting different components of a signaling pathway can effectively treat EGFR inhibitor-resistant NSCLC without resistance development.

This study characterizes the mutational and transcriptomic landscapes of a rare prostate basal cell carcinoma using single-cell sequencing, revealing unique gene expression and regulatory patterns.