L. Wang

This study systematically analyzes the distribution of metabolic pathways for five bacterial energy reserves across 8214 proteomes to reveal evolutionary patterns and correlations with genome reduction.

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

This study identifies MIR2052HG's role in regulating LMTK3 and ERα levels, contributing to aromatase inhibitor resistance in breast cancer.

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

This study designs nanoparticle-based influenza HA stem antigens that activate unmutated B cell receptors of broadly neutralizing antibodies, potentially enabling cross-group immunity.

This paper describes a cryo-EM sample preparation method that increases liposome density in EM grids using long incubation, enabling structural studies of liposomes and membrane proteins at low concentrations.

The paper determines the structure of the human BK channel using cryo-EM and observes a two-fold symmetry instead of the typical four-fold symmetry in ligand-modulated ion channels.

This paper analyzes college students' risk perception of pandemic influenza in Beijing using mental model interviews and the Delphi method to identify key risk factors and improve risk communication strategies.

The paper identifies an Xoo strain that bypasses xa13 resistance by not inducing clade III SWEET genes and is nearly identical to a Thai isolate.

This study compares the venom effectiveness of fire ant queens and workers, finding queen venoms act faster to knock down competitors than worker venoms.

This study identifies sex-specific predictors of survival in glioblastoma patients using MR imaging and clinical data.

This study examines how NaCl stress affects exogenous insecticidal protein expression in Bt cotton and its impact on Helicoverpa armigera larvae feeding behavior and nutritional parameters.

The paper describes a new standing rest behavior in Tibetan antelopes called 'Puppet behavior,' observed more frequently in males and linked to thermoregulation and anti-predation.

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

The paper uses single-molecule fluorescence microscopy to study Cas10 dynamics in type III CRISPR-Cas systems, revealing conformational changes that distinguish self from nonself RNA.

This study uses ReBiL2.0 to show that the C-terminal HVR-CAAX domain directs KRAS to colocalize with other prenylated proteins, impacting its signaling.

This study identifies divergent DNA methylation programs in sesame under drought and waterlogging stresses, showing their association with gene expression changes.

This study finds that TP53 mutations in breast cancer increase immunogenic activity, suggesting they could be a biomarker for immunotherapy response.

This study investigates the role of NF-κB and STAT signaling in Drosophila's response to Herpetomonas infection, showing their importance in parasite clearance and intestinal dynamics.

This study shows that high glucose diet extends the lifespan of post-reproductive C. elegans through UPR activation, independent of FOXO.

This study identifies estrogen signaling in arcuate Kiss1 neurons as a key regulator of sex-dependent bone density in female mice, revealing a novel neuroskeletal pathway.

This study shows PARP inhibitors trigger an immune response via the STING pathway, enhancing immune checkpoint blockade efficacy regardless of BRCA mutations.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

The paper develops a qPCR assay for quantifying Leishmania parasite burden in mouse models, using a conserved single-copy gene to improve accuracy over existing methods.

This study identifies EZH2 as a p53 mRNA-binding protein that enhances translation of gain-of-function p53 mutants, promoting cancer growth and metastasis, and shows that inhibiting EZH2 causes synthetic lethality in these cells.

This paper uses alchemical free-energy calculations to predict how Abl mutations affect inhibitor affinity, achieving accurate results for clinical mutations.

This study examines how elevated CO2 affects the development and food utilization of Mythimna separata larvae feeding on Bt maize infected with nitrogen-fixing bacteria.