S. Yu

This study evaluates the adjuvant and immunomodulatory effects of NKTT320, a humanized monoclonal antibody that activates iNKT cells, showing enhanced immune responses and inflammation resolution.

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

The paper describes a modified fluorescence reduction neutralization assay for quantitatively assessing SARS-CoV-2 neutralizing antibodies in clinical samples, demonstrating its efficiency and accuracy.

The paper characterizes 44 Arabidopsis UMAMITs, showing their localization and function as amino acid exporters, providing insights into their evolutionary role and transport properties.

This study shows that the priming step is not required for NLRP3 inflammasome activation in human monocytes, as nigericin and IL-37 can trigger caspase-1 activation and cytokine release without prior priming.

Genetically induced disturbance of amino acid homeostasis sequentially triggers responses to abiotic stresses and plant defenses to pathogens in Arabidopsis through undefined sensing mechanisms.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

This study shows that restoring glucocerebrosidase in muscle tissue reduces protein aggregation in both muscle and brain in a Drosophila model of Parkinson's disease by regulating extracellular vesicle content.

This study compares spindle dynamics in mitosis and meiosis I using fission yeast, showing Klp2 maintains meiotic spindle stability with Ase1, but not mitotic spindles.

This study evaluates preclinical models of lung cancer drugs and finds no significant linear trend between preclinical success and drug approval.

This study develops a finite element model of bilateral human semicircular canals to analyze cupular expansion and deflection during head rotation, showing their mechanical roles in vestibular function.

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.

This study shows IL-1RA inhibits esophageal cancer progression by suppressing VEGF through the PI3K/NF-κB pathway, suggesting it as a potential therapeutic target.

This study identifies EPS8 as a host factor that facilitates influenza A virus uncoating by delaying nuclear import of ribonucleoprotein complexes.

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

This study characterizes the pyruvate dehydrogenase complex E1 alpha and beta subunits of Mycoplasma synoviae, showing their surface localization and binding to plasminogen and fibronectin, which contribute to adhesion.

The paper shows that tibrovirus glycoproteins can enter human, bat, and nonhuman primate cells, but replication resistance varies among cell types.

This study examines how biogas slurry affects soil nutrients and economic traits of Camellia oleifera fruits, finding that higher application rates improve soil fertility and fruit yield.

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

The paper shows wild-type human γD crystallin catalyzes aggregation of its W42Q variant through disulfide bond transfer, revealing a redox mechanism relevant to protein aggregation in oxidizing environments.

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.

This paper develops a logic-based method to represent and resolve conflicts in phylogenomic node concepts across competing avian evolutionary reconstructions.

This study shows that EPAC1 promotes ANXA2 translocation to endothelial cell surfaces, enhancing plasminogen to plasmin conversion and fibrinolysis.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.