Y. Huang

This study shows PD-L1 maintains IFN-gamma signaling in human pluripotent stem cell-derived macrophages, essential for their development and inflammatory function.

This paper uses CpHMD simulations to identify H168 as an interior pH sensor in hHv1, supporting previous electrophysiological findings.

This study examines how different developmental temperatures affect survival and morphology in Heliconius erato butterflies, finding higher egg and larval mortality at higher temperatures and morphological changes in adults.

This paper shows that human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection via ACE2 and demonstrates antiviral efficacy of remdesivir and GC376.

The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.

This paper develops and benchmarks a high-throughput, robust proteomics method using Zeno SWATH DIA for analyzing cynomolgus monkey and human samples, showing improved sensitivity and coverage for metabolic disease studies.

This study designs a modified SARS-CoV-2 Spike antigen with increased RBD exposure and immunogenicity, showing improved neutralizing antibody responses in mice.

This study shows that LNP-based vaccines induce time- and dose-dependent anti-PEG antibodies in rats, with immune memory and accelerated blood clearance upon re-injection.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

This study develops a multimeric antibody platform (Multabody) that enhances neutralization potency and breadth against SARS-CoV-2 and its variants through avidity and multi-specificity.

This study investigates the spatiotemporal dynamics of microbial engraftment in the gut following fecal microbiota transplantation using a murine model.

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

This study shows that matrix softening influences stretch-induced cellular memory and fibroblast activation, with a model predicting activation levels based on ECM properties.

The paper tests Darwin's hypotheses on alien plant invasion success by analyzing phylogenetic relationships across invasion stages and environmental contexts.

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

This study tracks changes in extracellular vesicle concentration and small RNA expression during SIV infection and ART in macaques, identifying dynamic shifts in miRNAs and U6 RNA associated with viral load.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

This study evaluates the in vitro antiviral efficacy of Artemisia annua hot water extracts against SARS-CoV-2 omicron variants and subvariants, finding IC50 values within assay variation limits.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

This study investigates how tetraspanin 4 mediates migrasome formation through a two-stage mechanism involving membrane tension and cholesterol.

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.