C. Smith

This study identifies previously unknown translated ORFs in Mycobacterium tuberculosis using ribosome profiling, revealing pervasive translation of short ORFs that may contribute to evolutionary innovation.

The paper reports the X-ray structure of a public TCR recognizing a SARS-CoV-2 Spike-derived epitope and shows its activation of polyfunctional CD8+ T cells in recovered patients.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

The paper investigates how overlapping genes in HIV-1 balance selective forces, finding functional segregation where each protein spaces its residues to accommodate the other's functional sites.

The paper identifies 365 novel small ORFs in E. coli using ribosome profiling with antibiotics to stall ribosomes at start and stop codons, showing many encode unstable proteins not under purifying selection.

The paper describes a public engagement event called 'Superbugs: A Pop-up Science Shop' that aimed to increase awareness of antimicrobial resistance through an interactive experience in a shopping center, reaching 6,566 visitors.

This study introduces SNaPP, a method combining bioinformatics and chemical synthesis to discover novel bioactive peptides inspired by natural products, identifying 14 antibacterial peptides including activity against multidrug-resistant bacteria.

The paper shows dynein and kinesin motors balance microtubule network mechanics, affecting cell shape, adhesion, and mechanosensing through opposing actions on microtubule organization.

This study uses UAV-based phenotyping to analyze maize nitrogen responses over time, identifying genetic regions and candidate genes associated with phenotypic traits.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.

This study evaluates an adjuvanted SARS-CoV-2 RBD nanoparticle vaccine in macaques, showing robust immune responses and protection against viral challenge and variants.

A SARS-CoV-2 Spike ferritin nanoparticle vaccine induces broad neutralizing antibodies and protects nonhuman primates against respiratory infection and disease.

The paper identifies CD49f-expressing subsets of human regulatory T cells with distinct transcriptional profiles and functions linked to ulcerative colitis disease activity.

The paper shows that acquiring a megaplasmid can either sensitize or increase resistance to nalidixic acid in different Pseudomonas strains, depending on their genomic background.

This study shows that therapeutic paracetamol doses with antioxidants during early rat development cause long-term behavioral changes, indicating oxidative stress mediators do not fully prevent neurodevelopmental effects.

This study shows that elevated temperatures in Poland led to reduced armor in threespine sticklebacks over 90 years, linked to smaller body size.

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

This study identifies CASCADES, a lncRNA that regulates stemness in glioblastoma cancer stem cells by epigenetically controlling SOX2 expression.

This study shows that tailocins can prevent Pseudomonas syringae infection in Nicotiana benthamiana by targeting specific strains and demonstrates that heritable resistance mutations do not explain tailocin failure.

The paper uses historical data to show that rising Southern Ocean temperatures negatively affect Antarctic blue whale foetus growth through impacts on krill abundance.

The paper shows BRI1 phosphorylates DA1 to inhibit its growth-repressing activity, maintaining cell proliferation during leaf growth in Arabidopsis.

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

The paper develops a method to isolate and characterize large extracellular vesicles using imaging flow cytometry, showing a correlation between EV size and marker expression.

The paper identifies a gene variant affecting petal size in Arabidopsis by altering auxin availability through changes in a membrane protein's expression.

This paper develops an artificial microbiome-selection method to engineer salt-tolerant microbiomes for the plant Brachypodium distachyon, showing significant fitness improvements under sodium- and aluminum-sulfate stress.

This study identifies PsaE's role in regulating psaA in Yersinia pestis, showing its temperature- and pH-dependent expression and binding sites across the genome.