H. Lee

The paper studies microbial community dynamics in an anaerobic digester treating solid organic waste, finding specific microbial correlations with methane production and feedstock composition.

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

This study identifies the Rac-NOX2 complex as a driver of redox signaling in FLT3-mutant AML, showing that inhibiting NOX2 reduces key signaling pathways and enhances response to FLT3 inhibitors.

This study predicts water deer range expansion and dispersal routes in Northeast Asia using MaxEnt and circuitscape, identifying key habitats and potential conservation corridors.

This study shows that YAP/TAZ hyperactivation in mesangial cells drives diabetic nephropathy by stabilizing N-Myc, leading to cellular impairments and disease progression.

This study shows PROM1 is crucial in lipid rafts for liver regeneration by recruiting GP130 and activating the IL6-GP130-STAT3 pathway.

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

This study shows Wnt/PCP signaling promotes breast cancer metastasis by enhancing pro-invasive protrusions in leader cells during collective migration.

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

This paper introduces an adaptive ensemble refinement method for protein structures using MDFF and RADICAL-Cybertools, improving correlation with cryo-EM density maps by 40%.

This study compares PEG and acidification methods for virus concentration in water, finding PEG provides significantly better recovery for MS2 and HAdV41.

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

This paper uses AI-enabled multiscale computational microscopy to study SARS-CoV-2 Delta variant in respiratory aerosols, revealing atomic-level insights into airborne transmission.

This study shows that bacterial acetyltransferase effectors directly acetylate RIN4 T166, activating RPM1-dependent immunity in Arabidopsis, and that SOBER1 suppresses this by deacetylating the same residue.

This study identifies Phostensin as a regulator of integrin activation in lymphocytes by stabilizing the MIT complex through Rap1 dephosphorylation, leading to lymphoid organ population and T cell-mediated colitis.

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

The paper shows slow-growing microbes can coexist with faster-growing species in multi-resource environments due to differences in diauxic lags, despite being excluded in single-resource environments.

The paper shows slower microbial mutants can outcompete faster ones in spatial growth by forming dented V-shaped sectors, challenging the assumption that faster expansion always leads to dominance.

This study evaluates CT-P59's antiviral activity against Delta and its variants, showing reduced in vitro potency but effective in vivo neutralization and symptom remission in mice.

This paper describes the genetic engineering of methylotrophic bacteria to utilize gadolinium for growth, demonstrating potential for safer gadolinium-based contrast agents and recovery from waste.

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

This paper identifies a novel non-covalent inhibitor of SARS-CoV-2 main protease through high throughput virtual screening, validated by biochemical assays, X-ray crystallography, and molecular dynamics simulations.

The paper identifies TPX2 amplification in late-passaged hESCs as a driver of mitotic aberrations through transcriptome and genomic analysis.

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

The paper calculates the mechanical energy required to cyclize a DNA origami tile with an inherent twist using molecular dynamics simulations.

The paper introduces the Allen Cell and Structure Segmenter, an open-source toolkit for 3D segmentation of intracellular structures in fluorescence microscopy images, achieving high accuracy through classic and deep learning workflows.

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.