H. Zhu

This study shows that recombinant human MG53 protein protects cardiomyocytes from ischemia-reperfusion-induced oxidative stress by preserving mitochondrial integrity.

The paper analyzes H5N1 influenza virus evolution in humans and ducks in Cambodia, finding human-adapting mutations but limited within-host evolution due to selection pressures.

This study investigates the intestinal absorption of morroniside using a Caco-2 cell model, finding pH- and temperature-dependent transport and involvement of efflux proteins.

This paper identifies and characterizes 359 RXLR effectors in nine Pythium species, revealing evolutionary patterns and functional roles in host interactions.

The paper analyzes 4997 16S rRNA gene sequences to reveal high taxonomic diversity and cosmopolitan distribution of myxobacteria, with many uncultured taxa and habitat-specific preferences.

The paper introduces GLAMS, a method using glycosyltransferase labeling and mass spectrometry to identify sialylation linkages at the glycopeptide level, successfully identifying 1,236 linkage-specific sialoglycopeptides from human serum.

This study identifies distinct molecular profiles in Hispanic/Latino gastric cancer patients, including a high rate of CDH1 germline mutations linked to aggressive clinical outcomes.

This study identifies small molecule activators of human fumarate hydratase through quantitative high-throughput screening, revealing compounds that enhance FH activity without being substrates or redox agents.

The paper identifies point mutations that mimic allosteric effectors in human liver pyruvate kinase to validate potential drug targets for treating diabetes.

The paper develops a high-content Virion Display (VirD) array of human GPCRs to profile their biochemical activities and identifies potential drug targets.

This paper develops a portable 2D gas chromatography device with machine learning to diagnose ARDS from breath samples, achieving 87.1% accuracy.

This study compares the ATPase mechanisms and microtubule interactions of NOD and KID chromokinesins, revealing distinct structural and biochemical pathways for similar functions during cell division.

The paper assesses RNA folding specificity in mRNA and noncoding RNA, finding that specific folding is more evolutionarily adaptive and functionally significant.

This study shows that mitotic regulators and the SHP2-MAPK pathway promote insulin receptor endocytosis and feedback regulation of insulin signaling, improving insulin sensitivity when feedback is blocked.

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

This paper introduces a method using NMR spectroscopy to map protein conformational landscapes by comparing experimental and expectation spectra, enabling de novo structure determination.

The paper curates a database of virus-host receptor interactions and identifies common features of viral receptors, showing their role in cross-species transmission.

This study shows that polyploidy in the liver suppresses tumorigenesis while hyperdiploidy accelerates it in mutagen and high fat models.