J. Wu

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

OsNLP1 rapidly responds to nitrogen availability, enhances nitrogen uptake and assimilation, and holds great potential in promoting high yield in rice.

This study shows that knocking out rice OsPQT3 enhances resistance to abiotic stresses and increases grain yield under salt stress conditions.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This study identifies ATI1 and ATI2 as cargo receptors for MSBP1 in a starvation-induced ER-phagy pathway in Arabidopsis, distinct from ER-stress-induced pathways.

This study identifies new epigenetic and genetic biomarkers for esophageal cancer using cfDNA and combines SALP-seq with machine learning.

This study identifies OsNLP4 as a master regulator of nitrogen use efficiency in rice, showing it improves yield and NUE through transcriptional regulation of nitrogen-related genes.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

This study investigates whether intravenous ICG can label immune cells in the human retina and finds it is insufficient for robust labeling in blood or retina.

The paper identifies diverse putative e-pilin genes from environmental metagenomes using updated aromatic density thresholds, expanding known e-pili diversity in metal-rich ecosystems.

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

The paper integrates transcriptome and proteome data from Pseudomonas syringae in Arabidopsis to reveal gene regulation patterns influenced by plant immunity.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study assesses the vulnerability of 604 North American bird species to climate change under different warming scenarios and finds that mitigation is needed to reduce vulnerability.

This study assesses climate change risks to 544 North American bird species under two warming scenarios, finding higher risk with unmitigated warming and significant impacts from extreme weather events.

This study evaluates how adding Chinese herbal medicine residues affects antibiotic resistance genes and bacterial communities in chicken manure composting, finding increased ARG removal with higher residue addition.

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

This paper shows overexpression of ELO2 in yeast increases complex sphingolipids, improving osmotic tolerance and cell survival under high salt conditions.

This study identifies EPRS as a key regulator of proline-rich pro-fibrotic gene translation in cardiac fibrosis, showing its role in promoting fibrosis and identifying potential therapeutic targets.

This study compares anaerobic microbial communities involved in dechlorinating different HCH isomers, identifying key bacteria and revealing shifts in community composition based on substrate.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.

This study compares two methods for expanding human corneal endothelial cells in vitro, finding that low mitogenic conditions better preserve cell identity and that senescence occurs with continuous passaging.