J. Yang

This study evaluates the methodological quality of animal studies using the SYRCLEs risk of bias tool, finding significant differences between Chinese and English studies.

The paper analyzes bacterial diversity succession in compost made from pig manure and wood chips using 16S rRNA gene analysis, showing shifts in microbial phyla over composting stages.

The paper identifies a key residue in a GPCR dimer using in-cell structure characterization and shows its impact on dimerization and signaling.

This study investigates the association between baseline alpha-2-macroglobulin levels and radiation-induced toxicities in thoracic radiotherapy patients, finding a link with esophagitis and developing predictive models for toxicity.

This study monitors cytokine dynamics in mouse infection models and evaluates their diagnostic performance for bacterial bloodstream infections.

The paper shows that siRNA with a 5-nucleotide motif suppresses DNA-mediated IFN and cytokine signaling by inhibiting IFI16-DNA binding.

This study shows ATRX deficiency in glioma causes genomic instability via G-quadruplex DNA, and G4 stabilization can be therapeutically targeted.

This study systematically analyzes the distribution of metabolic pathways for five bacterial energy reserves across 8214 proteomes to reveal evolutionary patterns and correlations with genome reduction.

This paper determines the structural basis of how Rpn13 recognizes K48-linked Ub chains through a bivalent interaction, revealing a mechanism for proteasomal selectivity.

The paper shows that precise 3D printed geometric structures influence stem cell differentiation without exogenous signaling molecules.

This paper produces transgenic cassava with high amylose starch by silencing BE1 or BE2 genes, showing differences in starch properties between the two gene silencing lines.

This study identifies a deletion in TMPRSS6 associated with reduced hemoglobin and improved blood viscosity in Tibetan pigs adapted to high altitude.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

This study identifies granzyme B as essential for CD8+ T cell killing of Theileria parva-infected cells, showing its role in granule exocytosis and Bid activation.

The paper investigates genome size variation in Zea mays across altitudinal gradients, finding natural selection drives genome size changes through repeat content and linking it to flowering time and cell division rates.

This study evaluates the GenoType MTBDRplus and MTBDRsl assays for detecting drug-resistant Mycobacterium tuberculosis in Beijing isolates, showing high sensitivity for rifampicin and INH resistance, and their potential as supplementary diagnostic tools.

This study identifies microRNA mimics that enhance taxane-induced apoptosis in CRPC cell lines, suggesting potential therapeutic use to improve chemosensitivity.

This study compares CD4+ and CD8+ T cell recognition of Mtb-infected macrophages, finding CD8+ T cells poorly recognize infected macrophages despite strong immunodominant responses.

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.

The paper identifies three ZmSWEET13 paralogs as essential for phloem loading in maize, showing their role in carbon allocation and agronomical traits.

This study identifies SWEET11 and SWEET15 as critical for seed filling in rice by analyzing their expression, localization, and function in knockout mutants.

This study assesses the short-term stability of 21 amino acids in dried blood spots under simulated global health conditions, finding that some amino acids degrade while others increase in concentration under high temperature and humidity.

This paper demonstrates a synthesis-free PET imaging method for brown adipose tissue and TSPO using Disulfiram and 64CuCl2, showing TSPO as a biomarker for BAT mass.