K. Hao

IFNγ initiates TLR9-dependent autoimmune hepatitis in DNase II deficient mice

This study shows that IFNγ initiates TLR9-dependent autoimmune hepatitis in DNase II deficient mice by promoting monocyte recruitment and lymphocyte activation.

Spatial Localization Ability of Planarians Identified Through the Light Maze Paradigm

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

Diving Behavior Reveals Humidity Sensing Ability of Water Deprived Planarians

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

Isolation and characterization of fucosylated extracellular vesicles based on a novel high-throughput GlyExo-Capture technique

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

LACCASE is Necessary for Root Development in Salvia miltiorrhiza

This study shows that laccase genes are essential for root development and phenolic acid metabolism in Salvia miltiorrhiza using CRISPR/Cas9 gene knockout.

Research on the Influence of Different Temperature Conditions on the Microbial Community in Anearobic-Anoxic-Oxic process on the Plateau

The study examines how different low-temperature conditions affect microbial communities in an Anearobic-Anoxic-Oxic wastewater treatment process on the plateau, finding temperature impacts on specific bacterial abundances.

Evolution of regulatory signatures in primate cortical neurons at cell type resolution

This study identifies cell-type-specific regulatory changes in human, chimpanzee, and rhesus macaque cortical neurons, revealing human-specific regulatory elements linked to language and psychiatric disorders.

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

Modeling disease progression in newly diagnosed type 2 diabetes

This study develops a mechanistic model to quantify T2DM progression, showing that early diagnosis and intervention are critical for preserving beta-cell function and glycemic control.

Gut microbiota density influences host physiology and is shaped by host and microbial factors

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.