M. Guo

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

The paper examines how host plant species and nitrogen fertilization affect rhizosphere microbiomes in maize and soybean, identifying specific microbial taxa responding to these factors.

This paper identifies TspA as a new T7SS substrate in S. aureus, showing it mediates intra-species competition by membrane depolarization and growth inhibition in vivo.

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

This study uses a mechano-osmotic model and experiments to show gap junctions amplify spatial volume variations in multicellular spheroids due to proliferation-induced solid stress.

This paper introduces a microporous membrane sensor capable of detecting DNA at sub-aM concentrations through optimized mass transport and electrical resistance measurement.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

The paper measures SARS-CoV-2 RNA concentration in aerosols from different areas of Wuhan hospitals during the COVID-19 outbreak and finds that aerosol transmission is possible under certain conditions.

This paper develops a method to produce human amniotic epithelial cells-only membrane with higher purity and clinical potential for wound healing.

This study identifies LAMCORE cells as the source of lymphangioleiomyomatosis, showing their uterine neural crest origin and identifying potential biomarkers and therapeutic targets.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

This paper introduces faster deconvolution and multiview fusion methods, achieving speedups of 10 to several thousand-fold over previous approaches.

The paper identifies that MSR1 signaling via K63-polyubiquitylation activates JNK, promoting a pro-inflammatory switch in IL-4 activated macrophages.

This paper classifies lung adenocarcinomas into six subtypes based on EGFR, KRAS, and TP53 mutations, finding associations with prognosis and validating the classification against clinical outcomes.

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.

This paper introduces a method combining instant structured illumination microscopy with TIRF to achieve higher resolution and faster imaging of live samples near the coverslip.

This paper introduces a reflective imaging technique that enhances resolution, speed, and collection efficiency in light sheet microscopy without altering the microscope hardware.