T. Cui

Biomimetic fractal topography enhances podocyte maturation in vitro

This study shows that biomimetic fractal topography improves podocyte maturation in vitro by enhancing marker expression, cell polarity, and ECM remodeling via YAP signaling.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

SeMOE allows for quantitative glycan perception and exhibits anti-cancer potentiality

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

This study shows that the SARS-CoV-2 Spike protein causes long-term mitochondrial gene suppression, cardiac fibrosis, and reduced myocardial contractility in obese mice.

Inactivation of Vascular Stem Cells Suppresses Intimal Hyperplasia in Vein Grafts

The paper identifies vascular stem cells (VSCs) as a novel target for treating chronic vein graft failure by promoting intimal hyperplasia through paracrine signaling.

The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2

This study shows that the SARS-CoV-2 Spike protein disrupts lipid metabolism and autophagy, increasing lipotoxicity via ferroptosis, which can be mitigated by Nrf2 inhibition.

A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

Spike Protein of SARS-CoV-2 Activates Macrophages and Contributes to Induction of Acute Lung Inflammations in Mice

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

The consensus Nglyco-X-S/T motif and a previously unknown Nglyco-N -linked glycosylation are necessary for growth and pathogenicity of Phytophthora

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

This study identifies the Mocln1-calcineurin-TFEB-p62 pathway as mediating cardiac macroautophagy activation due to proteasomal malfunction.

Structural characterization of the N-terminal domain of the Dictyostelium discoideum mitochondrial calcium uniporter

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

Genome-wide CNV study and functional evaluation identified CTDSPL as tumour suppressor gene for cervical cancer

The paper identifies a deletion in CTDSPL as a strong genetic risk variant for cervical cancer, showing it suppresses tumor growth in vitro and in vivo.

Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World

The paper investigates the evolutionary history of FADS haplotypes in Native American populations, finding ancestral haplotypes under positive selection and potential health implications.