Y. Cheng

This study identifies vimentin's role in driving pro-inflammatory responses in alveolar macrophages during influenza infection, linking it to lung injury and mortality.

This study shows that vimentin is essential for metastasis in a mouse model of non-small cell lung cancer, as its loss impairs epithelial-to-mesenchymal transition and oxidative stress response.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

This study validates CFD simulations of nasal airflow using a 3D-printed model, showing high agreement at lower flow rates but significant deviation at higher flow rates.

This study determines the cryo-EM structures of human ferroportin bound to hepcidin and identifies mechanisms of iron homeostasis regulation.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

The paper introduces molecular goniometers using DNA origami to precisely orient DNA-binding proteins for cryo-EM, achieving a 6.5 Å structure of BurrH.

The paper identifies a parasitic symbiosis between perchlorate- and chlorate-reducing bacteria in the chlorine cycle, where perchlorate-reducing bacteria support chlorate-reducing bacteria by releasing chlorate.

This study shows eIF3 interacts with 80S ribosomes to enhance early translation elongation of mRNAs involved in mitochondrial and membrane functions, critical for muscle health.

This study investigates the transcriptome changes in grass carp brains under low temperature, identifying key pathways and genes involved in cold acclimation.

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

The paper shows that ATPase binding at one end of the 20S proteasome allosterically opens the opposite gate, promoting symmetric and asymmetric proteasome configurations.

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

This study shows that scaffold-free human mesenchymal stem cell tubes, with specific geometry and morphogen presentation, enhance endochondral bone regeneration in critical-sized femoral defects compared to loose hMSC sheets.

This study shows that the OR1D2 receptor mediates bourgeonal-induced CatSper activation through a G-protein-cAMP pathway in human sperm.

This study introduces a method using a single FT expression cassette in CRISPR/Cas9 to rapidly generate and identify transgene-free mutants in Arabidopsis.

The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.

The paper presents cryo-EM structures of SNF2h-nucleosome complexes with ADP-BeFx, revealing conformational states that suggest allosteric control through the nucleosome.

The paper presents cryo-EM structures of TRPV5 and its mutants, revealing structural features that explain its calcium selectivity and functional differences from other TRPV channels.

This paper creates a new mouse model with human-like sialylation patterns that improves human immune cell transplantation and HIV-1 infection sensitivity.

The paper presents four structures of the TPC1 ion channel's voltage sensor domain, revealing how activation occurs through conformational changes and Ca2+ binding.

This study examines how Pseudomonas aeruginosa interacts with other bacteria in mixed communities, finding it dominates biofilms but not planktonic environments, with H1 type VI secretion system and biofilm factors enhancing its fitness.

This study presents a cryo-EM structure of Patched, revealing its structural similarity to RND transporters and suggesting a role in cholesterol transport.

This study shows that M. tuberculosis RNA in extracellular vesicles activates host immune pathways, enhances bacterial killing, and reduces infection when combined with antibiotics.

This paper describes a method for preparing graphene-oxide cryo-EM grids that are suitable for high-resolution single particle cryo-EM.

This study differentiates dermal mesenchymal stem cells into vascular endothelial cells using endothelial cell line conditioned medium, showing high CD31 expression and angiogenic ability.