Y. Guo

This study identifies the origin of photoperiod non-responsiveness in barley by analyzing genetic variation and haplotype relationships in wild and domesticated barleys.

The paper investigates cohesin's role in neuronal gene expression in CdLS by analyzing transcriptomes and showing partial rescue of gene deregulation through cohesin reconstitution.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper shows that pDCs enhance innate immune defense against Aspergillus by amplifying neutrophil activity through CXCR3-dependent crosstalk during infection.

This study shows that rats with dorsomedial striatal lesions exhibit persistent cognitive flexibility deficits during reversal learning in a 3-CSRT task, despite normal accuracy acquisition.

This study investigates the genetic and environmental factors influencing growth rate variation in Arabidopsis thaliana, finding polygenic adaptation and environmental plasticity as key drivers.

This paper introduces a method for delivering cells to infarcted mouse hearts using echocardiography-guided percutaneous injection, showing improved cardiac function with repeated dosing.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.

This study develops an estrogen-inducible CRISPR/Cas9 system in Nicotiana tabacum and demonstrates its efficacy in inducing targeted mutagenesis of the NtPDS gene.

This study determines the cryo-EM structure of human ACE2 bound to the RBD of 2019-nCoV, revealing key interactions and differences compared to SARS-CoV.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This study develops a computer vision method to analyze C. elegans swimming behavior and identifies genetic factors influencing exercise-induced quiescence.

This study shows that acetyl-CoA from specific metabolic pathways enhances cardiac repair after myocardial infarction by promoting histone acetylation and antioxidant gene expression.

This paper identifies functional noncoding SNPs and their molecular mechanisms for 19 autoimmune diseases using multi-omics data and prioritizes drug targets.

dNEMO quantifies mRNA and punctate structures in single-cell time-lapse images using wavelet transforms and manual curation for accurate measurements.

This paper reveals the atomistic mechanism of NompC channel opening under intracellular compression using simulations and experiments, showing force transmission through ankyrin repeats and linker helices to the TRP domain.

This study shows that K14-dependent disulfides regulate epidermal homeostasis and barrier function through interactions with 14-3-3sigma and YAP1.

This study analyzes how uncorrected optical aberrations affect cryo-EM single particle reconstruction and provides a method to assess information loss.

The study identifies widespread distribution of beta satellite DNA across eukaryotes, suggesting multiple horizontal transfers and origins in primate ancestors.

The paper identifies proteins bound to metaphase ESC chromosomes and shows chromatin repressors are involved in maintaining chromosome compaction.

This study develops a rapid and efficient cowpea transformation system using embryonic axis explants, achieving transgenic shoot frequencies of 4.5 to 37%.

The paper assesses CRC screening and follow-up colonoscopy rates in a Chinese urban district, finding low participation and follow-up rates despite high CRC prevalence.

The paper analyzes the kinetic stability of the LMO2/LDB1 complex subunits and identifies LDB1 as a stabilizer and nucleator of the complex.

This study identifies a comprehensive atlas of B-lymphocytes in triple-negative breast cancer using single-cell RNA-sequencing and antigen receptor profiling, revealing their mature characteristics and prognostic significance.

This study shows that loss of cyclin A2 in colonic epithelial cells causes DNA damage, dysplasia, and colon inflammation, while high cyclin A2 expression is linked to better prognosis in colorectal cancer.

This study identifies gut bacteria, particularly Clostridiales, as a source of tacrolimus metabolism, producing less potent metabolites that may explain variable drug exposure after oral dosing.

The study examines EGFR exon19 mutation subtypes in non-small cell lung adenocarcinoma and finds that CSS mutations are associated with shorter progression-free survival compared to CD/CSS+SNV mutations.