Y. Guo

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

This study identifies ZmHXK7 as a maize hexokinase gene that improves salt tolerance in transgenic Arabidopsis by enhancing seedling growth and reducing stress inhibition.

The paper reprograms human B cells to express HCDR3 regions of HIV-1 bNAbs, enabling diverse and physiologic repertoires that efficiently bind HIV-1 antigens.

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

This study identifies σ3 as a reovirus virulence factor that suppresses PKR activation and stress granule formation, linking these functions to viral replication and myocardial injury in mice.

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

This study identifies HSP90 inhibitors as potential drugs for TSC1/TSC2 deficient cancer but finds rapamycin is more effective in vivo despite modest in vitro inhibition.

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

The paper compares transcriptomic profiles of different human trophoblast development models to identify differentially expressed genes and transcription factors.

The paper identifies a conserved mechanism involving ferritin proteins that enhances cold survival in nematodes and mammalian neurons by detoxifying iron-related reactive oxygen species.

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study shows that RUNX1 addiction is a therapeutic target in acute lymphoblastic leukemia, as inhibiting RUNX1 activity spares normal hematopoiesis and affects multiple genetic subtypes.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

This study shows that Atg5 in intestinal myeloid cells limits IL-12 secretion, preventing dysbiosis and inflammation by reducing IFN-gamma production.

The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.

This study identifies RBM39's role in promoting PRRSV proliferation by altering c-Jun phosphorylation and binding viral RNA.

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

This study shows that reovirus σ3 protein reduces interferon production and necroptosis by mechanisms unrelated to its dsRNA binding ability.

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

This study develops mouse monoclonal antibodies against SARS-CoV-2 spike protein that show neutralizing activity and are suitable for immunoassays and large-scale production.

The paper shows that His-tags affect particle orientation in cryoEM by modulating interactions with the water-air interface, suggesting their use for controlling preferred orientation patterns.

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.