J. Hu

The paper describes a new turtle species and investigates the function of carapace anterolateral processes using computational fluid dynamics.

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.

This study shows that ecological corridors increase plant root endospheric fungal species richness and reduce beta-diversity over time.

This study shows that weed species diversity and identity affect wheat root endospheric mycobiota and growth through neighbourhood effects.

This study identifies WNT4's role in regulating cancer metabolism through mitochondrial intracellular signaling in breast and gynecologic cancers, linking genetic variants to metabolic remodeling.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

The paper introduces a microbial risk score (MRS) framework to aggregate microbiome data into a predictive score for disease risk, validated across multiple cohorts.

The paper maps the localization of 1,032 chloroplast proteins in Chlamydomonas reinhardtii, revealing novel structures, spatial organization, and dual-organelle targeting.

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

The paper analyzes single-cell RNAseq data from metastatic castration-sensitive prostate cancer patients treated with anti-PD-1 immunotherapy, showing increased immune infiltrate and identifying therapy-resistant tumor subpopulations and druggable targets.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

This study shows that diet, particularly pollen polysaccharides, has a greater impact on shaping gut microbiomes in Asian honeybees than genetics.

This study uses CT scans to analyze the dental systems of three Jurassic ceratopsians, revealing tooth replacement patterns and dietary strategies that inform their evolution.

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.

The paper evaluates competition between pathogens and probiotic cleaners on indoor surfaces, finding negligible impact on community composition but functional differences in gene expression.

This study assesses the infectivity and immune evasion of the Omicron SARS-CoV-2 variant using pseudotyped viruses and neutralizing assays against convalescent sera and vaccinated individuals.

This study identifies MDR1 as a mediator of resistance to PROTACs in cancer cells and shows that combining MDR1 inhibitors with PROTACs enhances drug efficacy.

The paper uses quantum mechanical modeling to predict and analyze binding strengths of SARS-CoV-2 spike variants to the human ACE2 receptor, validating predictions experimentally.

This study shows that glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal communities in rat caecum microbiomes, with formulations causing more pronounced changes than glyphosate alone.

This study shows that reducing dermal white adipose tissue (dWAT) worsens EGFR inhibitor-induced skin rash in mice, and activating PPARγ with rosiglitazone improves skin function without affecting antitumor effects.

The paper demonstrates predictable emergent diversity and dynamics in microbial ecosystems by showing transitions between distinct dynamical phases as species number or interaction strength increases.

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.

The paper evaluates the neutralization efficacy of inactivated and RBD-subunit vaccines against SARS-CoV-2 B.1.617 and B.1.1.7 variants using a pseudovirus-based assay.

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

This study shows Rac1-GTP peaks and nadirs regulate protrusion and retraction lifetimes in fibrosarcoma cells by controlling traction forces.

This study shows that introducing probiotic bacterial consortia to tomato plants enhances growth by increasing rhizosphere microbiome diversity and abundance of rare taxa, rather than directly adding beneficial traits.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.