J. Lu

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

This paper shows that elevated -PheRS levels in Drosophila midguts induce tumor-like phenotypes by counteracting Notch signaling through its N-terminal domain.

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

Brief early adulthood rapamycin treatment in Drosophila and mice extends lifespan and maintains gut function through persistent intestinal autophagy and lysosomal enzyme levels.

This study shows that Delta variant SARS-CoV-2 spike proteins cause unique viral particle aggregation, which may affect infection kinetics.

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study analyzes the career outcomes of 2284 EMBL PhD and postdoc alumni from 1997 to 2020, showing 55% in academic research, 15% in industry, and 15% in science-related professions, with increased competition for PI roles but continued success in research careers.

The paper performs a proteogenomic analysis of chronic lymphocytic leukemia, identifies a new poor-prognosis subgroup (ASB-CLL) through proteomic profiling, and links it to clinical outcomes.

This study compares monoculture and stromal coculture for drug screening in hematological malignancies, finding that coculture reduces drug efficacy for many compounds but increases it for JAK inhibitors.

This study shows dexamethasone inhibits cytokine-induced DUOX2 and VEGF-A expression and DNA damage in pancreatic cancer cells and xenografts, but not in cytokine-unresponsive cells.

This paper develops a flexible 3D microelectrode array with PEDOT:PSS coating for high-quality EMG recording, achieving high SNR and improved impedance.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

This study identifies Prom1 and Notch as regulators of ciliary length and dynamics in multiciliated airway epithelial cells, contributing to mucociliary clearance and lung defense.

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

The paper shows hypoxia causes reversible depletion of PM PI4P and PIP2, disrupting electrostatic targeting of polybasic proteins, and identifies PI4KIII and its regulators as essential for maintaining their homeostasis.

This paper analyzes the evolution of SARS-CoV-2 through multiple strain waves, showing increasing mutations and suggesting a feedback loop between viral population size and mutation accumulation leading to the Delta strain.

This paper identifies a hyperexcitable variant of the TPC1 channel in Vicia faba, showing it differs from Arabidopsis in Ca2+ sensitivity and vacuole excitability.

This study shows that T cells can distinguish between C1 and C2 HLA-C groups due to differences in peptide presentation and TCR affinity.

This paper introduces a radially and azimuthally polarized microscope to measure single-molecule orientation and dynamics with high precision, revealing cholesterol-induced changes in membrane behavior.

This study shows that gp130/STAT3 signaling is essential for chondrocyte proliferation and anabolism, with loss leading to growth defects and cartilage dysfunction.

This paper compares the dynamic properties of SARS-CoV-1 and SARS-CoV-2 main proteases, finding that CoV-2 exhibits enhanced cross-chain coupling and dynamic allostery due to mutations.

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

This study investigates the interaction between the Myc and Mlx networks in liver regeneration and tumorigenesis, finding that the Mlx network plays a critical role in maintaining homeostasis and suppressing tumor formation.

This paper maps drug-microenvironment interactions in CLL to identify resistance mechanisms and patient subgroups, revealing how microenvironmental stimuli and genetic alterations influence drug response.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

The paper shows that SARS-CoV-2 exhibits substantial within-host genetic diversity, challenging the assumption of low diversity per infected individual and highlighting the importance of studying evolution within hosts.

This study identifies P2X4 purinergic receptors as a driver of aggressive prostate cancer and a potential therapeutic target through in vitro and in vivo experiments.