J. Lu

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

This study shows NOTCH1 mutations in B cell malignancies promote immune escape by upregulating PD-L1 and silencing HLA-class II, leading to poor clinical outcomes.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

The paper identifies amyloid-forming segments in SARS-CoV-2 Nucleoprotein and designs peptide inhibitors based on their atomic structures to target Covid-19.

This study identifies the localization and electrophysiological changes of Toxoplasma gondii-injected neurons in the mouse brain.

This study characterizes the reversible inhibition of SARS-CoV-2 and SARS-CoV Mpro by GC376, showing nanomolar Ki values and domain swapping in the drug-bound structures.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

This study analyzes Y-chromosomal STRs in Hazara and Baloch populations to reveal genetic diversity and historical interactions across the Durand-line.

This paper identifies rhodomyrtone as a broad-spectrum antiviral with activity against SARS-CoV-2 and other viruses, showing potent antiviral effects and low resistance potential.

This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.

The paper shows that elevated PheRS/FARS subunit expression promotes cell growth and proliferation independently of its aminoacylation activity and translation.

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

This study shows that patient-derived NFE2L2 mutants drive aggressive hepatoblastomas in mice by accelerating tumor growth and promoting necrosis and cyst formation.

This study identifies Tet2's role in regulating β cell responses to inflammation in Type 1 Diabetes, showing its protective effects against immune-mediated destruction.

This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.

The paper identifies lanthipeptide synthetases as key enzymes in the biosynthesis of 2-aminovinyl-cysteine motifs in thioamitides, revealing their role in dehydration and macrocyclization.

The paper introduces SMOLM, a single-molecule orientation localization microscopy technique, to measure orientation and spatial organization of lipophilic probes in lipid membranes, revealing compositional heterogeneity.

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

The study analyzes the endocast and bony labyrinth of a 400-million-year-old fossil fish, suggesting that early jawed vertebrate relationships may need to be re-evaluated.

The paper analyzes SARS-CoV-2 genome sequences to study mutation patterns and evolutionary dynamics, identifying mutations that may enhance viral fitness and provide insights for vaccine development.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

The paper introduces a new revisualization method that enables interchangeability between image processing and 3D visualization software, demonstrated through four case studies.

The paper investigates differential mast cell phenotypes in benign and cancerous prostate tissues and links higher numbers of tryptase-only mast cells to worse oncologic outcomes.

This study investigates how SARS-CoV-2 spike protein binding affects ACE2 enzymatic activity, finding it enhances proteolytic activity 3-10 fold via RBD domain interaction.