J. Wang

The paper develops a 2-step formate-reduction pathway by screening and engineering enzymes, but finds no in vivo biomass assimilation despite in vitro activity.

The paper uses a landscape-switching model to study chromosomal structural changes during cancerization and reversion, finding non-monotonic structural transitions and structural similarities to embryonic stem cells.

The paper introduces thiophosphopeptides that target the Golgi apparatus and selectively kill cancer cells through enzymatic self-assembly.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

The paper identifies a nadA mutation causing nicotinic acid auxotrophy in the AIEC strain NC101, enabling growth in minimal media and enhancing in vitro functional studies.

This paper develops an integrated mass spectrometry strategy to analyze the complex glycosylation of erythropoietin, identifying N- and O-glycan structures and their site-specific modifications.

This study identifies ciliary tip and base as distinct sites for EV shedding in C. elegans and shows ciliary trafficking machinery regulates EV biogenesis and signaling.

This study shows albendazole reduces endoplasmic reticulum stress in mice infected with Echinococcus multilocularis by modulating UPR-related proteins and miRNAs.

This study shows Kv1.3 is highly expressed in human PDAC and novel Kv1.3 inhibitors combined with chemotherapy significantly reduce tumor growth in mouse models.

This study identifies and characterizes six AcMNPV-encoded miRNAs, showing they regulate both viral and host genes through suppression or enhancement of target expression.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

This study produces SARS-CoV-2 virus-like particles in insect cells for vaccine development and research.

This paper presents a computationally designed dual-ring biobot that demonstrates robust forward motion and rotational steering through differential electrical stimulation.

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

This study evaluates GC-376's in vivo antiviral efficacy against SARS-CoV-2 in K18-hACE2 mice, showing reduced viral loads and inflammation but no improvement in clinical symptoms or survival.

The paper develops tTARGIT AAVs to precisely manipulate intersectional neuronal populations by combining Flp and Cre recombinases, demonstrating their use in targeting LepRbVMH neurons.

This study examines fungal co-occurrence networks along an elevation gradient on Mt. Norikura, finding that climate factors dominate network connectivity patterns, with significant declines between 700 m and 1500 m elevation.

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

This study examines how meteorological factors affect wheat irrigation water requirements in the Beijing-Tianjin-Hebei region from 2000 to 2019, showing trends and correlations with climate variables.

This study identifies the DAXX-SREBP axis as a driver of lipogenesis and tumorigenesis by showing its role in activating lipogenic gene expression and promoting tumor growth.

This study investigates the neuroprotective role of CTRP1 in TBI rats, finding it reduces inflammation and modulates autophagy through mTOR activation.

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

This study compares the molecular mechanisms of pluripotent reprogramming and malignant transformation, revealing shared and distinct features of cellular plasticity and identifying bHLH transcription factors as key regulators.

The paper re-analyzes NIH funding disparities, finding that lower award rates for African American or Black PIs are due to IC assignment, not topic choice.

The paper identifies binary and ternary protein interactions among SARS-CoV-2 replication/transcription complex components using a novel compartmentalization-based screening method.

This study shows that TFH-B cell interactions driven by neoantigens enhance anti-tumor CD8+ T cell responses in lung adenocarcinoma.

The paper analyzes immune cell variability in murine tumors using IHC and DIA, showing inter-tumor variation dominates and reveals compositional heterogeneity.

This paper investigates the catalytic mechanism of SznF, revealing an unusual N-nitrosation pathway involving electron shuttling without high-valent iron species.

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

The paper develops 16S rRNA sequence capture baits to improve microbial community characterization by balancing the advantages of amplicon and shotgun metagenomic methods.