J. Wang

The paper analyzes 155 Drosophila genomes to detect widespread introgression across nine monophyletic radiations, revealing both ancient and recent hybridization events.

The paper presents high-quality genome assemblies for 101 drosophilid lines using Oxford Nanopore sequencing, achieving high contig N50 and BUSCO completeness.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

This study shows that PPARD promotes pancreatic ductal adenocarcinoma in mutant Kras mice on high-fat diets, and its inhibition could be a therapeutic strategy.

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

This paper designs proteins with discontinuous functional sites using deep learning, eliminating the need for pre-defined secondary structures and enabling diverse scaffold generation.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

The paper evaluates the effect size, sample size, and power of Forced Swim Test assays in mice, finding large effect sizes and recommending increased sample sizes for reliable results.

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This study identifies two novel inhibitors of Neisseria gonorrhoeae that target ribonucleotide reductase, showing efficacy against multidrug-resistant strains in a mouse model.

This study identifies RaACE2 as a functional receptor for SARS-CoV-2 and RaTG13, and evaluates ACE2s from 16 species for their ability to mediate virus entry.

This study shows that inhibiting Fis1 improves endothelial function in diabetic vessels by enhancing NO availability and reducing mitochondrial ROS.

This study identifies 36 upregulated genes across SARS-CoV-2-infected respiratory tract cells, highlighting inflammatory and interferon response pathways linked to cytokine storms in severe COVID-19.

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

The paper characterizes the genomic distribution of Klebsiella pneumoniae complex in a hospital, finding high prevalence of K. pneumoniae sensu stricto and hypervirulent strains in liver isolates.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study uses GaMD simulations to elucidate the dynamic mechanism of Numb RNA binding to MSI1, providing insights for drug design targeting this interaction.

This study identifies four compounds with broad-spectrum antiviral activity against multiple coronaviruses, including SARS-CoV-2, by inhibiting viral Mpro and cathepsin L.

This study shows that human ILC2 cells can be activated by TLR4 signaling through LPS, leading to cytokine production and B cell activation, distinct from classical IL-33 activation.

This study shows that lack of Bifidobacteria in early life is linked to immune dysregulation, and B. infantis EVC001 reduces intestinal Th2 and Th17 responses while promoting Th1 polarization.