J. Zhang

The paper develops methylation-based models to predict maximum lifespan and other life history traits in mammals using data from 12,000 samples across 192 species.

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

This study generates new cell lines for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor to better study sarcomagenesis and develop therapies.

This study identifies PIP2 binding sites in Kv7.2 channels using simulations and electrophysiology, showing how PIP2 couples voltage sensor and pore domains during activation.

The paper characterizes the K18-hACE2 mouse model's response to different SARS-CoV-2 doses, showing dose-dependent disease severity and recovery, and compares it to human COVID-19 pathology.

The paper investigates trait-trait coevolution in yeast and flies, finding that natural selection, not pleiotropy, drives correlations between morphological traits.

The paper assesses the replicative fitness of SARS-CoV-2 B.1.1.7 variant in human organoid models and finds higher infectious virus production and fitness compared to an ancestral strain.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study shows YTHDF2, an m6A reader, enhances NK cell anti-tumor and anti-viral responses by regulating homeostasis, maturation, and effector function through STAT5 feedback and Tardbp interactions.

The paper tests hypotheses about stomatal size-density scaling in plants using macroevolutionary models and phylogenetic regression on 2408 species, finding support for the stomatal-area increase hypothesis for higher gmax.

This study shows that platelet HMGB1 in PRP enhances tendon healing in mice, with PRP from GFP mice promoting faster healing and better tissue organization compared to PRP from HMGB1 KO mice.

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

This study investigates the interaction between the apricot bud gall mite and its host, revealing hormonal changes that drive gall development and providing insights for pest management.

This study shows that dynein activation in Aspergillus nidulans is regulated by the nucleotide states of its AAA3 domain, with ATP hydrolysis and binding affecting LIS1 interaction and cargo binding.

This study investigates SARS-CoV-2 infection and seropositivity in pets from households with confirmed human COVID-19 cases, finding that 17% of pets had neutralizing antibodies and suggesting transmission from humans to pets.

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

AMFIP enables automatic multi-functional live-cell imaging by integrating hardware and software without extra costs or hardware, demonstrating its utility in mechanobiology studies.

This study investigates how Trichostatin A (TSA) affects IL-17A-induced transformation of MRC5 cells into myofibroblasts and identifies the TGF-β1/Smads signaling pathway as the mechanism.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.

This study shows that MFG-E8 promotes Ang II-induced arterial inflammation and remodeling in aging, and its deficiency reduces these effects.

The paper introduces an R package for generalizing hierarchical and variation partitioning in canonical analysis to improve model interpretation with multiple response variables.

This study examines how hibernation affects epigenetic aging in yellow-bellied marmots using epigenetic clocks and pacemakers, finding that aging slows during hibernation.

This paper introduces a multi-scale experimental design to study the effects of climate and land use on biodiversity and ecosystem services, achieving low correlations between environmental variables across scales.

This paper develops a p-ELISA method using a multiepitope fusion protein to diagnose bovine and goat brucellosis, achieving high sensitivity and specificity.