J. Zhang

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study identifies HSP90 inhibitors as potential drugs for TSC1/TSC2 deficient cancer but finds rapamycin is more effective in vivo despite modest in vitro inhibition.

This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.

This paper develops a robotic system and model-based approach to estimate viscous damping and stiffness in Parkinsonism, showing that these metrics decrease with deep brain stimulation and better differentiate rigidity changes than existing clinical scores.

This study identifies AGL16 as a negative regulator that suppresses stress response genes to balance growth and stress tolerance in plants.

This paper combines continuous granulation with 3D printing to improve dissolution rates and physical properties of a poorly water-soluble drug.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

The paper identifies two new NVT cargos bound by Nbr1-ZZ1 and reveals the structural basis of ZZ domain-mediated cargo recognition in selective autophagy.

This study develops FRET-based biosensors to screen for RyR modulators, identifying novel inhibitors and activators with therapeutic potential.

The paper identifies an immune gene signature linked to MGMT methylation in glioblastoma that predicts prognosis and immune response.

This study identifies seven new anti-CRISPR proteins and characterizes their mechanisms against Type I-C CRISPR-Cas systems in Pseudomonas aeruginosa, revealing co-evolutionary dynamics between MGEs.

This study shows that increasing semi-natural habitats in conventional cruciferous vegetable fields improves pest suppression by natural enemies, with effects varying by pest type and landscape scale.

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

This study identifies that TNBC cells recruit neutrophils by secreting TGF-β and CXCR2 ligands, promoting tumor progression.

This study evaluates undersampling correction methods for β-diversity to reduce γ-dependence, finding that diversity accumulation curves outperform null models in removing γ-dependence.

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

The paper shows that bacterial DNA recombination increases tRNA levels early in antibiotic stress, aiding resistance before efflux pumps or mutations.

This study shows that silencing lncRNA NEAT1 suppresses ESCC cell proliferation, migration, and invasion by regulating the miR-1299/MMP2 axis.

The paper introduces membrane contact probability (MCP) as a predictive metric for membrane proteins, showing it improves contact map and structure predictions.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

This study examines how positive and negative emotions affect false memory using EEG, finding higher false memory rates and distinct brain activation patterns in the positive emotion group.

This study investigates how TRPV4 ion channels in keratinocytes mediate UVB-induced inflammation by activating inflammasomes and MAPK signaling, leading to IL-1β secretion and pain.

This study shows that phosphorylation of TAX1BP1 by IκB kinases promotes its lysosomal degradation and enhances its ability to clear MAVS aggregates.

The paper presents a method to simultaneously measure multiple FRET pairs using donor photochromism, validated with biosensors for PKA, ERK, and calcium.

This study shows that replacing integrin α5 with a chimeric α5/α2 integrin reduces vascular remodeling and inflammation in mouse models.