J. Zhang

This study establishes a mouse model of post-traumatic joint injury and identifies Gli1+ mesenchymal progenitors as key contributors to arthrofibrosis and heterotopic ossification.

This study identifies c-Jun and JunB binding sites in ALK+ ALCL cells, revealing novel targets and a role for FAM129B in NPM-ALK signaling.

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

This study identifies multiple ParA/MinD ATPases in bacteria that coordinate the positioning of diverse cellular cargos, revealing specificity determinants and indirect regulatory interactions.

TANKBind improves drug-protein binding structure prediction by incorporating trigonometry constraints and functional block segmentation, achieving better performance than existing methods.

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

The paper investigates how crowding in developing mouse kidney tubules creates mechanical stresses in nephron-forming niches, revealing how spatial constraints influence branching and nephron formation.

This study uses mesoscopic tract-tracing data to improve fiber orientation distribution estimation in mouse brains via deep learning, enhancing tractography specificity without sacrificing sensitivity.

This study identifies kinesin-1 autoinhibition as a novel regulatory factor that facilitates dynein cargo initiation, distinct from LIS1-promoted dynein switching.

This paper presents an experimental microfluidic model to simulate herd immunity for a human coronavirus by varying cell proportions and observing transmission dynamics.

This study identifies durable microanatomical production lines in hematopoiesis that maintain blood cell production during stress and aging.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

The paper assesses butterfly species risk in western US states using heterogeneous data, finding high risk in certain families and highlighting species with broad ranges needing conservation attention.

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

The study identifies the wheat locus P2, associated with elongated glumes, as mapping to chromosome 6A and linked to ectopic expression of SVP-A1.

This study investigates the role of Q-tRNA modifications in inflammatory bowel disease, finding reduced QTRT1 expression and altered junction proteins in IBD patients and models.

The paper develops chemical labeling strategies to tag lipid-modified RNAs and identify new regulatory enzymes involved in prenylation.

This study shows that intestinal vitamin D receptor deficiency promotes breast cancer by causing gut dysbiosis, increased inflammation, and microbial translocation.

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

This paper identifies EmPIM as a target for anti-AE chemotherapy and demonstrates that in silico-designed compounds can inhibit parasite growth with reduced toxicity to human cells.

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

The paper examines factors affecting arthropod predation rates across different habitats and finds that landscape diversity, not climate, significantly influences predation in open herbaceous vegetation.

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

This paper introduces a method to rapidly image biomechanics with low irradiation using dual line-scanning Brillouin microscopy, demonstrating its application to study tumor spheroid mechanics.

The paper identifies MME+ fibro-adipogenic progenitors as the main adipogenic population in fatty infiltrated human skeletal muscle using single-cell RNA sequencing.

This study shows that air pollution particles promote lung cancer by hijacking peroxidasin to alter collagen crosslinking, impairing immune surveillance.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.