M. Chen

This study develops a mouse model to study occult colonization and antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae, identifying factors that predict susceptibility to outgrowth.

This paper introduces Nanotraps, functionalized nanoparticles that block SARS-CoV-2 infection by inhibiting spike protein-ACE2 interaction and triggering macrophage-mediated viral clearance.

The paper identifies PIKfyve inhibition as a strategy to block α-synuclein fibril escape from lysosomes, reducing aggregation spread in a human cell model.

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

This study shows that specific NRAS mutants drive melanoma formation in mice, with Q61R and Q61K being the most effective, while others like G12D or Q61Q are not.

This study shows that FGF21-PEG normalizes plasma glucose in two mouse diabetes models, even when insulin receptor function is impaired.

This study uses atomic packing frustration analysis to refine predicted protein structures, improving their quality through guided simulations.

This paper develops a photothermal nanoparticle conjugated with neutralizing antibodies to capture and inactivate SARS-CoV-2, showing efficient viral capture, photothermal effect, and inhibition of viral entry.

The paper compares embryo proper and suspensor transcriptomes across plants with different suspensor morphologies, identifying shared and specific transcription factors involved in early embryo differentiation.

The paper identifies OsMKK1 as a direct target of OsDMI3 and shows that OsDMI3-mediated phosphorylation of OsMKK1 is crucial for ABA signaling and stress responses.

The paper examines allele frequency differentiation at height-associated SNPs across continental populations and finds significant FST differences, suggesting polygenic adaptation, while polygenic scores show less consistent results.

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

This study shows that VAPYRIN suppresses defense mechanisms in Petunia hybrids during arbuscular mycorrhizal symbiosis by preventing PR gene induction and localized lignin accumulation.

This study shows that deleting Atm in p53-deficient brainstem gliomas enhances radiosensitivity, while p53 wild-type tumors respond to radiotherapy regardless of Atm status.

This study shows that 6β-naltrexol prevents neonatal opioid withdrawal in guinea pigs by blocking opioid dependence with high potency.

The paper uses cryo-ET to determine the 7 Å structure of the AcrAB-TolC efflux pump in Escherichia coli, revealing its activation mechanism through interprotein interactions.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper introduces Prox-seq, a method to measure proteins, protein complexes, and mRNA in single cells, demonstrating its ability to detect 91 protein complexes and thousands of mRNAs in T-cells and B-cells.

This study uses CRISPR screens to identify mechanisms increasing BCMA expression and enhancing anti-myeloma efficacy of BCMA-targeted therapies in multiple myeloma.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

This paper introduces FucoID, a method to detect and isolate tumor-specific antigen-reactive T cells from tumor-infiltrating lymphocytes using fucosyl-biotinylation, revealing distinct gene features and functional capabilities.

The paper shows that ionizing radiation disrupts oncogenic interactions between the fusion oncoprotein FUS-CHOP and the chromatin remodeler ISWI via phosphorylation of FUS-CHOP's prion-like domain, explaining radiation sensitivity in myxoid liposarcoma.

This study shows that increasing temperatures cause phytochrome B to disassemble from photobodies in Arabidopsis, with tissue-specific effects on phyB function.

SNAPSwitch quantitatively tracks protein, DNA, and nanoparticle localization in live cells using flow cytometry, showing distinct trafficking routes for different receptors.

This study investigates how juvenile hormone (JH) regulates flight capability in Bactrocera dorsalis, finding that JH levels correlate with flight duration and distance, and that JH III treatment enhances flight performance.

The paper generates a novel mouse strain with a tagged RanBP9 protein, enabling reliable detection and revealing its interaction with Nucleolin.

This study examines how landscape composition affects crop pest and pathogen abundance over time, finding that landscape simplification may increase risks in the following growing season rather than the current one.

This study shows integrin α6β4 signaling shifts DNA repair from homologous recombination to non-homologous end joining in TNBC, increasing sensitivity to cisplatin.

This study shows integrin α6β4 is downregulated in IDH1 mutant oligodendrogliomas, promotes glioma growth, and is linked to worse patient outcomes.

This paper demonstrates the use of a ClyA nanopore to monitor conformational changes of maltose-binding protein (MBP) in real time, revealing three distinct ligand-bound states corresponding to different reducing sugar isomers.