M. Chen

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

This study shows PPAR-delta drives metabolic reprogramming in pancreatic cancer, promoting metastasis, and its inhibition reduces invasiveness.

This study shows that the PHR2 gene regulates arbuscular mycorrhiza symbiosis by controlling phosphate starvation responses in rice, enhancing root colonization and phosphate uptake.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The paper isolates and characterizes two novel photosystem I supercomplexes from cyanobacteria, revealing the structure of the PSI octamer at near-atomic resolution.

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

The paper develops a small molecule for imaging immune cell activity in cancer immunotherapies and demonstrates its utility in predicting treatment outcomes.

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

This paper demonstrates a method for unidirectional transport of full-length proteins through nanopores using guanidinium chloride and machine learning to identify protein orientation and identity.

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.

This study shows LRP-1 supports tumour cell motility under ischemic conditions by coordinating two distinct signalling pathways involving Hsp90 and EGFR.

This study shows that OsLEC1 inhibits photosynthesis in rice embryos to promote seed dormancy by regulating hormonal pathways and gene networks.

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

This study shows that in silico predicted SARS-CoV-2 epitopes do not reliably elicit T cell responses against naturally presented epitopes.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

This study shows non-English-language science provides crucial evidence for global biodiversity conservation, expanding geographical and taxonomic coverage but often with less robust study designs.

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

This study identifies a p53-like transcription activation domain in PIF3 and shows that PHYB binding inhibits its activity, revealing a photoresponsive transcriptional switch in Arabidopsis.

This study reports cryoEM structures of two Latrotoxins (LaTXs) and proposes a cyclic oligomerization mechanism, revealing structural insights into their molecular action.

This paper isolates and characterizes a quinclorac-degrading bacterium, Cellulosimicrobium cellulans sp., showing 45.9% degradation efficiency and identifying two novel degradation products.

The paper measures the real-time folding of an outer membrane porin using single-molecule Forster Resonance Energy Transfer, revealing fast folding events despite slow ensemble kinetics.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.