M. Li

This study shows that engineering anthocyanin pathway in Artemisia annua cells does not prevent artemisinin biosynthesis, suggesting artemisinin can be produced in non-GT cells.

The paper fits a mosquito density model to Guangzhou data, identifies non-identifiable parameters, simplifies the model, and validates its applicability across seasons.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

This study uses super-resolution microscopy to visualize mitochondrial cristae and mtDNA interactions, revealing their dynamic relationship and distribution patterns under different cellular conditions.

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

This study shows that mycorrhizal fungi affect the genetic basis of mineral accumulation in maize, altering nutrient and toxic element concentrations in leaves and grain.

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

The paper isolates the first host-associated Psychrilyobacter strain from abalone gut and identifies its functional roles in host metabolism and health.

This study identifies SLFN12 as an HIV-1 restriction factor that inhibits viral replication and reactivation through codon-usage dependent post-transcriptional block in CD4+ T cells.

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

This study shows that calpain-2 expression in glioblastoma cells reduces TMZ-induced DNA damage and p53-dependent apoptosis, leading to chemoresistance.

This study identifies two progenitors of sweetpotato using horizontal transferred T-DNA and haplotype-based phylogenetic analysis, revealing its origin from a reciprocal cross and whole genome duplication.

This paper develops a super DNA-enzyme molecule (SDEM) that enables on-demand enzyme activity modulation with improved detection limits and reaction rates compared to free enzymes.

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

This paper introduces 3D Root Mesocosms for studying root systems and environmental fluxes in mature crops, showing high correlation between digital reconstructions and biomass measurements.

This study shows that Fragilariopsis cylindrus uses extracellular carbonic anhydrase for HCO3- uptake regardless of temperature changes, maintaining reliance on HCO3- even when CO2 solubility varies.

The paper identifies 27 Drosophila melanogaster genes orthologous to the mosquito cucoid gene, which establishes embryo polarity, and explores their evolutionary history and potential chromatin regulatory roles.

This study shows that DNA damage-induced O-GlcNAcylation of YTHDC1 enhances its m6A binding, promoting homologous recombination and genome stability.

This paper develops a standardized method to isolate and purify high-quality cardiomyocytes from murine hearts of all postnatal ages, revealing sex-specific genes and preserving cell morphology.

This paper develops a CRISPRa system in Aedes aegypti to transactivate endogenous genes, demonstrating its ability to overexpress developmental genes and suppress dengue virus.

This paper introduces MoTERNN, a recursive neural network that classifies cancer evolution modes from phylogenetic trees into four categories using simulated and real single-cell DNA sequencing data.

This paper identifies ALT in pediatric high-grade gliomas without ATRX mutations and links it to germline MMR variants.

The paper introduces MaGIC, a ctDNA profiling method that improves cancer classification and chemosensitivity prediction by reducing background noise from cfDNA.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This study shows obesity disrupts pituitary UPR, leading to NAFLD, and demonstrates that restoring pituitary UPR can ameliorate metabolic defects.

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

This study shows Ralstonia solanacearum alters root development in Arabidopsis through auxin-dependent and independent mechanisms, including promoting xylem differentiation and root hair formation.

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

This study links sulfur metabolism in deep-sea hydrothermal plumes to microbial biogeography and biogeochemical cycling using genomic data from 37 plumes across 8 ocean basins.