M. Li

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

This paper updates the Arabidopsis thaliana PeptideAtlas proteomics resource, identifies 78.6% of the predicted proteome, and uses a machine learning model to predict the dark proteome.

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

This paper develops a potent MAPK13-14 inhibitor, NuP-3, which reduces airway inflammation and mucus production in human airway models and minipig disease models.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This study shows that switching to a low-calorie diet late in life extends fly lifespan and reduces mortality, while switching to a high-calorie diet shortens lifespan and increases mortality.

This study uses cryo-electron tomography to reveal that PRC1-CBX8 condensates are porous and dynamic, challenging the notion of rigid chromatin compaction in gene repression.

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

The paper generates a high-confidence binary protein interaction network for Drosophila using yeast two-hybrid screens and integrates it with existing data to create a comprehensive reference network.

This study shows that sterile soil prebiotics can restore gut microbial diversity and alleviate anxiety-like behavior and intestinal barrier issues caused by antibiotic exposure across generations in mice.

This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.

The paper develops a method to overexpress, purify, and reconstitute the lysine transporter Ypq1 in yeast vacuoles, demonstrating its pH-gated transport function and lysine-dependent stability.

The paper investigates how PAP1 activates anthocyanin biosynthesis in red Artemisia annua cells and how 2,4-D affects this process by downregulating PAP1 and pathway gene expression.

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

The paper examines mitochondrial gene rearrangements in Diprionidae, showing their potential as phylogenetic markers in Hymenoptera evolution.

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

This study analyzes mitochondrial phylogeography of Qinghai-Tibetan Plateau grassland caterpillars, revealing speciation patterns and genetic diversity linked to geological and climatic factors.

This paper introduces noise-robust deconvolution algorithms for fluorescence microscopy using multi-resolution analysis regularization, improving resolution and SNR across various imaging techniques.

This study identifies Fkbp5 as a regulator of epithelial cell quiescence-proliferation transition via Akt signaling in zebrafish using transcriptomics and genetic approaches.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

This study identifies electron transfer mechanisms in Methanothrix thermoacetophila during direct interspecies electron transfer with Geobacter metallireducens using transcriptomics.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.