T. Zeng

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity

This study shows that Decitabine's DNA damage response depends on DNMT activity levels, with different repair pathways activated under varying conditions.

Scaling the Discrete-time Wright Fisher model to biobank-scale datasets

This paper introduces an algorithm to scale the Discrete-Time Wright Fisher model to large datasets, enabling efficient and accurate population genetic inference at biobank scale.

The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells

This study shows that promoters and transcription factors coevolve antagonistically in animals and mutually in plants, leading to different transcriptional network transitions.

Out of the Qinghai-Tibetan Plateau and get flourishing - the evolution of Neodon voles (Rodentia: Cricetidae) revealed by systematic sampling and low coverage whole genome sequencing

This study identifies six new Neodon species using systematic sampling and low coverage whole genome sequencing, revealing the Qinghai-Tibetan Plateau as the origin and highlighting climate change and geographic isolation as drivers of speciation.