T. Zhang

This study analyzes the evolutionary patterns of ACE2 binding affinity to SARS-CoV-2 spike protein across 247 vertebrates and identifies key amino acid mutations driving affinity divergence.

This study identifies Wnt ligands as binding partners of APP, showing that Wnt3a stabilizes APP while Wnt5a targets it for degradation, with functional consequences for neuronal development.

The paper investigates the proteomic composition of the pathogen-host interface in cholera using a rabbit model and identifies SP-D as a novel intestinal defense factor.

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

This study investigates the tumor-suppressing functions of hsa-miR-654-5p in lung cancer through bioinformatic analysis and in vitro experiments, revealing its role in inhibiting EMT, proliferation, and migration.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

This study distinguishes between SARS-CoV-2-specific T cell memory and cross-reactive T cell responses using negative controls and dose-response analysis.

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

The paper introduces improved positive controls (CERI, CEFX, CPI) for assessing T cell function in PBMC compared to CEF peptides, showing CEF's limitations in CD8+ T cell and APC evaluation.

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

The paper compares predicted and actual CD8+ T cell epitopes for HCMV pp65 antigen across ten HLA-A*02:01-matched individuals, finding no correlation between predicted epitope rankings and actual immune dominance.

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

This study shows that Muc2 mucin restricts Listeria monocytogenes spread from the intestine and affects its population dynamics during infection.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

The paper tests if thermal preference variation in Drosophila melanogaster reflects a bet-hedging strategy across regions and finds evidence supporting this evolutionary strategy.

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

This study shows that deleting SHP in the intestine of mice impairs their response to cholic acid, affecting bile acid levels and transporters without altering FXR mRNA.

The paper shows that autophagy is required for self-incompatible pollen rejection in transgenic Arabidopsis thaliana lines by disrupting autophagy genes and observing increased self-pollen fertilization.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

The paper shows that metastatic tumors drive HSPCs to differentiate into monocyte-dendritic progenitors via IL-6, promoting metastasis.

This study evaluates the immunogenicity and protective efficacy of different serotype variants of a live oral cholera vaccine in a germ-free mouse model, finding minimal impact of O1 serotype variation on vaccine function.

This study shows ZmMTOPVIB is essential for DSB formation and bipolar spindle assembly in maize meiosis, with conserved functions in monocots.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study uses an open microfluidic coculture system to show that human kidney epithelial cells promote kidney-specific gene expression in endothelial cells through paracrine signaling.

This study investigates the relationship between trimethoprim concentrations and antimicrobial resistance gene prevalence in river sites across the Thames catchment, finding significant seasonal and land-use correlations.

This study identifies that mammalian ATG9s bind to LC3 via UIM-UDS interaction to drive autophagosome formation.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.