T. Zhang

This paper analyzes scientific and patent trends in PD-1/PD-L1-targeting antineoplastics using scientometrics and patentometrics, identifying key research and development focuses.

This study evaluates the bactericidal activity of Artemisia annua and Artemisia afra extracts against Mycobacterium tuberculosis and Mycobacterium abscessus, finding that A. annua extracts are more effective than pure artemisinin.

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

This study compares non-Cochrane nursing systematic reviews with their PROSPERO-registered protocols, finding widespread discrepancies with few explanations.

The paper shows that siderophores trigger extracellular superoxide production in carbon-starved Arthrobacter strains when carbon sources recover, and highlights interference of DTPA in superoxide quantification.

The paper develops CM93, a novel EGFR inhibitor with improved targeting and brain penetration, showing better efficacy and safety in mouse models of EGFR-mutant NSCLC and brain metastases.

The paper uses mathematical models and focus reduction assays to show that influenza virus neutralization and antibody consumption can lead to bistable growth kinetics, explaining reinfection and vaccine efficacy.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The paper identifies Pangolin-CoV as a close relative of 2019-nCoV, showing high genomic similarity and key amino acid conservation in the S1 protein, suggesting it may be an intermediate host.

This study isolates and expands SOX9+ renal epithelial cells from adult humans, showing their ability to regenerate kidney tissue in mice.

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

This study uses bioluminescent imaging to monitor HIV-1 infection dynamics in humanized mice during and after antiretroviral therapy, showing rebound in previously infected lymphoid tissues.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.

This paper develops a framework to prioritize antibiotic resistance genes (ARGs) based on risk factors and identifies high-risk ARGs for global action.

This study demonstrates that dual protease type XIII/pepsin digestion improves HX-MS analysis of histone tails by providing better resolution and peptide overlap.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study examines how shift-work affects carotid artery health and cerebral blood flow in SHR and WKY rats, finding increased blood pressure, arterial thickening, and reduced blood flow.

The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.

This study shows auxin induces TMK1 nanoclustering and lipid nanodomains, which, with microtubule feedback, establish cell polarity in Arabidopsis.

The paper investigates the role of CSI1 and microtubules in cell wall architecture during acid growth in Arabidopsis hypocotyls, finding that CSI1-dependent crossed-polylamellate walls are essential for auxin-induced cell elongation.

The paper develops a method to image sub-organellar actin dynamics using fluorescent actin nanobodies and finds ER-associated actin drives organelle fission.

This study identifies a sulfotransferase that links light signals to jasmonate signaling in plants, enabling prioritization of shade avoidance over defense.

This study develops a microscale collagen gel contraction assay to investigate fibroblast-induced ECM contraction and intercellular communication in asthma-related fibrosis.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.

This study shows that the live-attenuated cholera vaccine HaitiV provides protection against V. cholerae in mice and their offspring through immunological mechanisms, not vaccine transmission.