T. Zhang

The paper isolates deep-sea PVC bacteria and identifies eukaryotic-like features, suggesting membrane fusion drives eukaryogenesis.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

This study investigates how Aeromonas hydrophila infection affects the metabolomic response and gut microbiota of Charybdis japonica, showing that certain bacteria and metabolites help resist infection.

The paper identifies Top2a as a key factor in social behavior development through PRC2 and H3K27me3 in zebrafish and mice.

This study examines the physiological responses of Solenaia oleivora to short-term salinity exposure, showing changes in hemolymph osmolality, protein and amino acid concentrations, ion levels, and gill morphology.

The paper uses computational methods to predict miRNA-target regulatory modules in soybeans under abiotic stress and identifies stress-related modules with gene ontology enrichment.

This study shows azacytidine limits SARS-CoV-2 infection and protects mice by disrupting viral RNA methylation.

The paper shows that ROS-RET signalling requires uninterrupted electron flow through the ETC and is lost during ageing in flies, leading to persistent mtROS production and reduced stress adaptation.

This paper introduces a method to monitor phloem and xylem reconnections in grafted watermelon seedlings using specific fluorescent tracers and finds that vascular reconnections are not timely separated in self-grafted watermelon.

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

The paper introduces iwa-miRNA, a web-based tool for interactive annotation of plant miRNAs using sRNA-Seq data and manual curation.

The paper investigates microbiota dynamics and assembly patterns in a large water diversion canal, finding deterministic processes shape bacterial communities while stochasticity dominates micro-eukaryotic communities.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

The paper fine-maps melanoma-associated genomic regions to identify novel causal SNPs in the MTAP/CDKN2A and CASP8 loci using sequencing, variant filtering, and functional assays.

This study investigates SARS-CoV-2 infection in placentas from infected pregnant women, finding that the virus infects syncytiotrophoblast cells and triggers maternal immune cell infiltration.

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

This study examines how Drosophila larvae respond to repeated mechanical vibrations, identifying behavioral transitions and habituation patterns.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This study evaluates novel oral tuberculosis regimens containing TB47, clofazimine, and linezolid, showing fast-acting sterilizing activity and no relapse in a mouse model.

The paper simulates fluorescence imaging in the oral cavity using a 3D model and compares simulated data with real camera data to quantify porphyrin fluorescence relative to other fluorophores.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study develops a drug-resistant recombinant BCG vaccine that enhances second-line TB treatment efficacy in a murine model of drug-resistant tuberculosis.

This study identifies cyclocreatine as a dual-action inhibitor of prostate cancer by blocking the phosphagen system and increasing S-adenosyl methionine levels.

This study characterizes SARS-CoV-2 RBDs produced in CHO and HEK293 cells, revealing distinct glycosylation patterns and confirming O-glycosylation at T323, with comparable functional binding properties.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.