W. Wei

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

This study compares the composition of normal stress granules and mutant FUS assemblies in stressed cells, identifying molecular differences and their impact on cellular stress responses in ALS-FUS.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

The paper introduces a method to profile cell-type-specific secretomes in vivo and identifies novel secreted proteins and dynamic changes in hepatocyte secretomes.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The paper uses transient ablation and single-cell RNA sequencing to study mTEC development, revealing a transit-amplifying population preceding Aire expression and a branching model of differentiation.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

This study shows that lysosomal activity in C. elegans regulates mitochondrial fission through vitamin B12 metabolism, linking lysosomal dysfunction to mitochondrial dynamics and micronutrient deficiency.

This paper develops a genetically defined, syngeneic organoid platform for ovarian cancer to evaluate combination therapies and finds genotype-specific responses to immunotherapy and chemotherapy.

The paper identifies 2019-nCoV related coronaviruses in Malayan pangolins, suggesting they may be intermediate hosts for the virus.

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

The paper creates a high-resolution global root biomass map using field measurements and environmental data, finding lower root biomass than previous studies due to improved methods and data.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

This study identifies PeGATA transcription factors in moso bamboo and shows they regulate shoot growth and rhizome development via GA signaling pathway.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.

The paper identifies a pathway where Golgi localized β1-adrenergic receptors stimulate PI4P hydrolysis via PLCε to promote cardiac hypertrophy, distinct from surface receptor signaling.

This study uses simulations to show that A2 domain unfolding in vWF multimers under shear flow occurs preferentially near the center of unraveled multimers, with threshold shear rates inversely related to multimer length.