W. Wu

This study examines a lamin A/C mutation in mice, revealing structural changes in nuclear filaments and chromatin organization linked to striated muscle disease.

This study identifies lung macrophages that kill helminths by depleting arginine through differential activation of recruited monocyte-derived alveolar macrophages.

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

This study evaluates three fecal immunoassay technologies for detecting canine Echinococcus infection in China, finding that sensitivity is lower than expected and further development is needed.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

This study examines how wrinkle structures in the veins of Asian ladybird hind wings affect deformation and flight performance, suggesting bioinspiration for micro air vehicle wing design.

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

The paper investigates the role of xa5 in BLS resistance by analyzing transcriptome changes in Xa5-RNAi rice lines compared to wild-type, finding enhanced cell death gene responses.

The paper identifies PIWIL3's localization in bovine oocytes, its interaction with TDRKH and PNLDC1 in a mitochondrial complex, and its role in piRNA-mediated transposable element suppression.

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

This study identifies high levels of enterovirus antibodies in cerebrospinal fluid of children with acute flaccid myelitis compared to controls, suggesting a causal role for non-polio enteroviruses.

The paper identifies co-occurring RAS-MAPK pathway alterations in MET exon 14 skipping mutation positive lung cancers that limit response to MET inhibitors and suggests combining MET and MEK inhibitors to overcome resistance.

This study shows that Capicua regulates neural stem cell proliferation and lineage specification by controlling Ets factors, with implications for oligodendroglioma development.

The paper shows that obligate methylotrophic methanogens in marine sediments can use CO2 to produce methane and incorporate significant amounts of dissolved inorganic carbon into lipids.

The paper uses single-cell RNA sequencing to analyze antler stem cells, finding they form a homogeneous population with unique gene expression patterns and potential as a model for regeneration.

This study identifies ETV4 and CCNE1 as targets of the CIC-DUX4 fusion oncoprotein, showing their roles in sarcoma metastasis and tumor growth, and highlights therapeutic strategies targeting the CCNE-CDK2 complex.

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

This paper introduces a multimodal interferometric imaging platform to study nanoscale structure and macromolecular dynamics in live cells, revealing a new phenomenon called cellular paroxysm induced by UV light.

This study identifies ANRIL as a key lncRNA promoting HTLV-1-induced ATL cell proliferation through interaction with EZH2 and activation of NF-κB.