W. Wu

The paper shows that nuclear spatial organization, particularly near spindle-pole bodies, influences centromere identity by facilitating CENP-ACnp1 incorporation.

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

This study generates SARS-CoV-2 virus-like particles using baculovirus expression, showing they induce neutralizing antibodies and protect against variant challenge in a hamster model.

This paper develops a portable 3D microfluidic chip for rapid single-cell antibiotic susceptibility testing and bacterial quantification, showing improved speed, sensitivity, and accuracy compared to traditional methods.

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study investigates the cellular localization and cytoskeleton interactions of reflectin proteins, revealing their localization preferences and potential mechanisms for nuclear entry and cytoskeletal binding.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

This study analyzes rhizosphere bacterial diversity of Angelica dahurica var. formosana across different sites and varieties, finding stable communities and key taxa linked to yield and quality.

The paper describes the Forget-Me-Not dHCP study, which acquires high-resolution diffusion MRI data from unfixed post-mortem neonatal brains and presents preliminary analyses of cortical and white matter structures.

This study compares the in vitro antifungal activity of SHR8008, a novel tetrazole, to itraconazole and fluconazole against Candida and Cryptococcus species, finding SHR8008 to be significantly more potent.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

The paper shows LIN37 prevents DNA end resection and HR in quiescent cells independently of 53BP1, unlike in cycling cells.

This study identifies and analyzes nuclear receptors in Platyhelminth species, revealing two distinct evolutionary lineages and novel features in parasitic flatworms.

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

This study shows that combining anti-GD2 and anti-CD47 antibodies enhances anti-tumor responses by recruiting macrophages and disrupting the GD2:Siglec-7 interaction in GD2+ cancers.

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

The paper shows that adenosine from extracellular ATP via A2BAR on intestinal epithelial cells promotes type 2 immunity against helminth infection.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.