Z. He

This study investigates how age-matching between fecal microbiota transplantation (FMT) donors and aged recipients affects microbiota establishment and resilience, finding that mismatched age may reduce resilience against inflammation.

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

This paper investigates the concordance between two methods for detecting positive selection and finds that they often disagree, suggesting negative selection variation may mislead positive selection inferences.

The paper tests the synergistic anti-cancer effects of pyrazolopyrimidinones combined with cold atmospheric plasma against glioblastoma cells and identifies two prodrugs that show enhanced cytotoxicity in combination.

This study examines sieve tube structural variation in Austrobaileya scandens, finding small sieve plate pore radii and hydraulic segmentation that may affect energy distribution in lianas.

This study constructs a ceRNA network in metastatic melanoma to identify prognostic markers and therapeutic targets, finding miR-3662 may be used in treatment.

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

This study examines how acute isolation affects vocal and non-vocal social behaviors in male and female mice during same-sex and opposite-sex interactions, finding stronger effects in females.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

This study shows platinum nanoparticles reduce intracellular reactive oxygen species and protect cells from cold atmospheric plasma-induced cytotoxicity in both cancerous and non-cancerous cell lines.

This study identifies unreported memory retrievals in free recall tasks by analyzing inter-response times, revealing three distinct silent effects and proposing a minimal model to explain them.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study validates a new associative transcriptomics pipeline in Brassica oleracea to identify vernalisation response candidates, finding miR172D and BoFLC.C2 as potential markers.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

This paper introduces a method to identify microbiome features affecting outcomes while controlling for confounding variables, showing improved accuracy in agricultural microbiome studies.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This paper develops a whole-cell biosensor to detect DAPG-producing bacteria in grassland soil, showing high sensitivity and enabling isolation and population dynamics analysis.

This study shows microglia regulate retinal capillary constriction via fractalkine-Cx3cr1 signaling and RAS pathway, with dysfunction occurring early in diabetic retinopathy.

The paper identifies compounds that inhibit SARS-CoV-2 3CLpro enzyme activity, with auranofin showing strong inhibition and potential for COVID-19 treatment.

The paper re-examines evidence for adaptive DNA sequence evolution using MK and PAML tests on Drosophila and Arabidopsis data, finding little overlap and suggesting unreliable results.

The paper investigates whether apparent signals of positive selection in DNA sequences are actually due to relaxed negative selection, finding strong fluctuations in negative selection strength across species.

This study presents cryo-EM structures of pannexin 1 from Xenopus tropicalis and Homo sapiens, revealing its heptameric architecture and molecular sieve mechanism for ATP release.

This study shows that ursolic acid inhibits GBM cell migration and induces JNK-dependent lysosomal cell death.

This study identifies distinct CD8+ T cell subsets in non-lymphoid tissues during infection and cancer, revealing their functional roles and regulatory mechanisms.

The paper uses single-cell RNA sequencing to study CD8+ T cell differentiation during infection, revealing molecular determinants and functional heterogeneity in tissue-resident memory cells.

This study shows that combining cold atmospheric plasma with silver nanoparticles significantly increases cytotoxicity in glioblastoma cells through enhanced nanoparticle uptake and oxidative stress.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.