C. Yu

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

This study identifies multiple triggering factors for mutation repair in RNA viruses and shows that cell-to-cell movement enhances mutation repair, opposing the Muller ratchet effect.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

The paper quantifies how Erk signaling dynamics influence immediate-early gene expression in cells and shows that response heterogeneity is not fully explained by Erk activity.

The paper identifies a novel IRES in WYMV RNA2 with variable eIF4E-binding sites and synergistic effects that enhance IRES activity.

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

This study compares the robustness of microbiota association inference using stool, swab, and mucosal tissue samples in a larger cohort, finding that mucosal samples yield less consistent results than stool or swab.

This paper develops a high-throughput assay to identify inhibitors of HSV-1 ICP0 transactivation, identifying 76 potential inhibitors from 19,000 compounds.

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

The paper identifies glutaric aciduria type 3 as a naturally occurring trait in 129 substrain mice due to SUGCT deficiency, showing its impact on metabolite accumulation.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

This study identifies thermocycles as the primary cue for diurnal gene regulation in Brachypodium distachyon, showing that most rhythmic transcripts adjust their period in constant conditions.

This paper introduces lipid-mediated insertion of TLR ligands as a non-genetic method to engineer immune cells, showing controlled delivery and persistent activation without permanent genetic modification.

This paper introduces LiveFISH, a method to visualize real-time chromosomal rearrangements in living cells, and demonstrates its application in detecting gene-editing induced translocations.

The paper shows DHTKD1 and OGDH share in vivo substrate overlap and form a hybrid ketoacid dehydrogenase complex, with implications for GA1 therapy.

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

This study investigates the interaction between S100A4 and S100A1, revealing that S100A4 inhibits cell proliferation by blocking the RAGE V domain-S100A1 interaction.