J. Huang

This study shows that magnetite enables methanogens to adapt to higher cathode potentials in electrochemical reactors, enhancing electromethanogenesis.

The paper identifies a human-specific BRCA2 variant that reduces DNA repair ability, suggesting positive selection for decreased BRCA2 function in human evolution.

This study identifies RBM39's role in promoting PRRSV proliferation by altering c-Jun phosphorylation and binding viral RNA.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

This study develops VLP-based vaccines targeting the HIV-1 FP8 epitope, showing they induce high-titer FP8-specific antibodies and effective neutralizing responses in mice.

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

This study investigates the evolutionary dynamics of non-coding regions in pancreatic cancer, finding higher mutational burden in noncoding DNA and similar mutational spectra between enhancers and coding DNA.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study shows that e-cigarette vapor causes mitochondrial DNA damage, which activates TLR9 and promotes atherosclerosis in mice.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

This study uses scRNA-seq on pancreatic cancer biopsies to characterize tumor-stromal heterogeneity and ligand-receptor interactions, showing its utility over patient-derived organoids for precision oncology.

This study shows CRAMP is required for macrophages to eliminate phagocytosed E. coli via autophagy, involving ATG5, LC3-II, and LAMP-1.

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

ConnecTF integrates TF-target gene interactions to build and refine gene regulatory networks in plants, demonstrating its utility through three case studies.

The paper profiles the crotonylome in Small Cell Lung Cancer tissues compared to normal lung tissues, identifying unique protein crotonylation patterns in cancer-related pathways.

This paper identifies Bl-Eng2 as an adjuvant that enhances cell-mediated immunity against fungal and viral infections through structural and mechanistic insights.

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

This study identifies TMIGD1 as a tumor suppressor that arrests the cell cycle in colon cancer cells and is downregulated in human CRC, correlating with poor survival.

This study identifies a novel epitope on the hMPV F protein recognized by neutralizing antibodies, revealing structural dynamics and glycan interactions important for vaccine design.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This study traces carbon and nitrogen flows in soil microbial communities influenced by plant-AMF associations and substrate types, revealing how these interactions affect decomposition and nutrient cycling.

This paper evaluates how well thermodynamic folding and binding free energies predict the fitness of beta-lactamase mutants using experimental data and computational models.